We have developed a graphical user interface (GUI) to the Genetics Computer Group (GCG) Sequence Analysis Package using the OPEN LOOK interface. The software consists of pulldown menus and window interfaces to the GCG programs. This provides experienced users with methods to expedite the entry of complex commands and inexperienced users easy mouse-driven access to the GCG programs using both IBM-compatible machines and Macintoshes running X server software.

Computer support for research in biotechnology has developed rapidly and has provided several tools to aid the researcher. This report describes the capabilities of new computer software developed in this laboratory to aid in the documentation and planning of experiments in molecular biology. The program, POLLUX, provides a graphical medium for the entry, edit and manipulation of DNA constructs and a textual format for display and edit of construct descriptive data. Program operation and procedures are designed to mimic the actual laboratory experiments with respect to capability and the order in which they are performed. Flexible control over the content of the computer-generated displays and program facilities is provided by a mouse-driven menu interface. Programmed facilities for mutagenesis, simulated cloning and searching of the database from networked workstations are described.