SUMMARY: ALOHOMORA is a software tool designed to facilitate genome-wide linkage studies performed with high-density single nucleotide polymorphism (SNP) marker panels such as the Affymetrix GeneChip(R) Human Mapping 10K Array. Genotype data are converted into appropriate formats for a number of common linkage programs and subjected to standard quality control routines before linkage runs are started. ALOHOMORA is written in Perl and may be used to perform state-of-the-art linkage scans in small and large families with any genetic model. Options for using different genetic maps or ethnicity-specific allele frequencies are implemented. Graphic outputs of whole-genome multipoint LOD score values are provided for the entire dataset as well as for individual families. AVAILABILITY: ALOHOMORA is available free of charge for non-commercial research institutions. For more details, see http://gmc.mdc-berlin.de/alohomora/

UNLABELLED: HaploPainter is a user-friendly pedigree-drawing application with special features for easy visualization of complex haplotype information. It has been developed to facilitate gene mapping in Mendelian diseases in terms of fast and reliable definition of the smallest critical interval harbouring the underlying gene defect. HaploPainter is written in Perl and may be used for visualization of haplotypes calculated by any of the common linkage programs. With special features like haplotype compression or the ability of marker section cut-out it particularly addresses the requirements for viewing large haplotypes as obtained by using for genome scans high-density marker panels of many thousands of single nucleotide polymorphisms (SNPs). AVAILABILITY: http://haplopainter.sourceforge.net/ CONTACT: [email protected].

The areas of application of hypermedia technology, combined with the capabilities that hypermedia provides for manipulating structure, create an environment in which version control is very important. A hypermedia version control framework has been designed to specifically address the version control problem in open hypermedia environments. One of the primary distinctions of the framework is the partitioning of hypermedia version control functionality into intrinsic and application-specific categories. The version control has been used as a model for the design of version control services for a hyperbase management system that provides complete version support for both data and structural entities. In addition to serving as a version control model for open hypermedia environments, the framework offers a clarifying and unifying context in which to examine the issues of version control in hypermedia.