Existing pharmaceutical information extraction research often focus on standalone entity or relationship identification tasks over drug instructions. There is a lack of a holistic solution for drug knowledge extraction. Moreover, current methods perform poorly in extracting fine-grained interaction relations from drug instructions. To solve these problems, this paper proposes an information extraction framework for drug instructions. The framework proposes deep learning models with fine-tuned pre-training models for entity recognition and relation extraction. In addition, it incorporates an novel entity pair calibration process to promote the performance for fine-grained relation extraction. The framework experiments on more than 60k Chinese drug description sentences from 4000 drug instructions. Empirical results show that the framework can successfully identify drug related entities (F1 3 0.95) and their relations (F1 3 0.83) from the realistic dataset, and the entity pair calibration plays an important role (~5% F1 score improvement) in extracting fine-grained relations.

The proliferation of sensor devices and services along with the advances in event processing brings many new opportunities as well as challenges. It is now possible to provide, analyze and react upon real-time, complex events in urban environments. When existing event services do not provide such complex events directly, an event service composition maybe required. However, it is difficult to determine which event service candidates (or service compositions) best suit users' and applications' quality-of-service requirements. A sub-optimal service composition may lead to inaccurate event detection, lack of system robustness etc. In this paper, the authors address these issues by first providing a quality-of-service aggregation schema for complex event service compositions and then developing a genetic algorithm to efficiently create near-optimal event service compositions. The authors evaluate their approach with both real sensor data collected via Internet-of-Things services as well as synthesised datasets.