Accurate traffic flow forecasting is crucial for intelligent transportation systems and relies on effectively modeling complex spatio-temporal dependencies. Although recent graph-based deep learning methods have achieved promising results, most focus on pairwise neighbor relationships, limiting their ability to capture higher-order spatio-temporal interactions in the traffic network. To overcome this limitation, we propose a novel Multi-source information driven Spatio-Temporal HyperGraph learning for traffic forecasting (MSTHG), which is designed to capture richer relational and semantic information. MSTHG introduces a multi-source hypergraph fusion strategy that jointly models dynamic high-order spatial and temporal correlations. Specifically, we build a spatial hypergraph based on geographical proximity to represent high-order spatial dependencies, and a temporal-trend hypergraph leveraging mutual information to capture nonlinear similarities among traffic series. To enhance the semantic richness of node representations, we integrate key daily and weekly information along with periodic features derived from Fast Fourier Transform (FFT). Following the obtained hypergraph, node representations are learned through a hypergraph convolutional network and subsequently processed by a GRU-MLP fusion module, which is designed to capture both local and global temporal dependencies. Extensive experiments on real-world benchmark datasets demonstrate that MSTHG outperforms state-of-the-art baselines. The source code is https://github.com/April-leng/MSTHG.git.