Introduction . Coronary artery disease (CAD) is one of the main causes of death all over the world. One way to reduce the mortality rate from CAD is to predict its risk and take effective interventions. The use of machine learning‐ (ML‐) based methods is an effective method for predicting CAD‐induced death, which is why many studies in this field have been conducted in recent years. Thus, this study aimed to review published studies on artificial intelligence classification algorithms in CAD detection and diagnosis. Methods . This study systematically reviewed the most cutting‐edge techniques for analyzing clinical and paraclinical data to quickly diagnose CAD. We searched PubMed, Scopus, and Web of Science databases using a combination of related keywords. A data extraction form was used to collect data after selecting the articles based on inclusion and exclusion criteria. The content analysis method was used to analyze the data, and based on the study’s objectives, the results are presented in tables and figures. Results . Our search in three prevalent databases resulted in 15689 studies, of which 54 were included to be reviewed for data analysis. Most studies used laboratory and demographic data classification and have shown desirable results. In general, three ML methods (traditional ML, DL/NN, and ensemble) were used. Among the algorithms used, random forest (RF), linear regression (LR), neural networks (NNs), support vector machine (SVM), and K‐nearest networks (KNNs) have the most applications in the field of code recognition. Conclusion . The findings of this study show that these models based on different ML methods were successful despite the lack of a benchmark for comparing and analyzing ML features, methods, and algorithms in CAD diagnosis. Many of these models performed better in their analyses of CAD features as a result of a closer look. In the near future, clinical specialists can use ML‐based models as a powerful tool for diagnosing CAD more quickly and precisely by looking at its design’s technical facets. Among its incredible outcomes are decreased diagnostic errors, diagnostic time, and needless invasive diagnostic tests, all of which typically result in decreases in diagnostic expenses for healthcare systems.

The definitive diagnosis of acute lymphoblastic leukemia (ALL), as a highly prevalent cancer, requires invasive, expensive, and time-consuming diagnostic tests. ALL diagnosis using peripheral blood smear (PBS) images plays a vital role in the initial screening of cancer from non-cancer cases. The examination of these PBS images by laboratory users is riddled with problems such as diagnostic error because the nonspecific nature of ALL signs and symptoms often leads to misdiagnosis. Herein, a model based on deep convolutional neural networks (CNNs) is proposed to detect ALL from hematogone cases and then determine ALL subtypes. In this paper, we build a publicly available ALL data set, comprised 3562 PBS images from 89 patients suspected of ALL, including 25 healthy individuals with a benign diagnosis (hematogone) and 64 patients with a definitive diagnosis of ALL subtypes. After color thresholding-based segmentation in the HSV color space by designing a two-channel network, 10 well-known CNN architectures (EfficientNet, MobileNetV3, VGG-19, Xception, InceptionV3, ResNet50V2, VGG-16, NASNetLarge, InceptionResNetV2, and DenseNet201) were employed for feature extraction of different data classes. Of these 10 models, DenseNet201 achieved the best performance in diagnosis and classification. Finally, a model was developed and proposed based on this state-of-the-art technology. This deep learning-based model attained an accuracy, sensitivity, and specificity of 99.85, 99.52, and 99.89%, respectively. The proposed method may help to distinguish ALL from benign cases. This model is also able to assist hematologists and laboratory personnel in diagnosing ALL subtypes and thus determining the treatment protocol associated with these subtypes. The proposed data set is available at https://www.kaggle.com/mehradaria/leukemia and the implementation (source code) of proposed method is made publicly available at https://github.com/MehradAria/ALL-Subtype-Classification.