Abstract Social sciences are increasingly recognized as significant for building a sustainable world since the social perspective can assist researchers in other fields in navigating public controversy and designing more responsible interaction mechanisms between the natural and social systems. However, the question arises: to what extent do natural sciences rely on social science research in their studies? Examining life science publications from seven PLoS journals, this paper attempts to characterize the volume and trajectory of citations from life sciences to social sciences. We explore three core questions: To what extent do life sciences cite social sciences? What actors in the life sciences are citing social sciences? Which actors in the social sciences are being cited? Our analysis estimates social sciences influence 15%–19% of life science publications, contributing to 1.1%–1.5% of references in 2018. Social science citers are found across peripheral and central topics of life science disciplines. Cited social science publications exhibit various levels of interdisciplinarity and achieve the greatest citation impact among peers. Citations to social sciences are prevalent in both theoretically and methodologically oriented sections. We show empirically the increasing impact of social sciences on the development of the life sciences.