Deep-learning methods (especially convolutional neural networks) using magnetic resonance imaging (MRI) data have been successfully applied to computer-aided diagnosis of Parkinson's Disease (PD). Early detection and prior care may help patients improve their quality of life, although this neurodegenerative disease has no known cure. In this study, we propose a FResnet18 model to classify MRI images of PD and Health Control (HC) by fusing image texture features with deep features. First, Local Binary Pattern and Gray-Level Co-occurrence Matrix are used to extract the handcrafted features. Second, the modified ResNet18 network is used to extract deep features. Finally, the fused features are classified by Support Vector Machine. The classification accuracy rate for MRI images reaches 98.66%, and the findings demonstrate that the model can successfully differentiate between PD and HC. The suggested FResnet18 provides greater performance compared with existing approaches, and it is shown through extensive experimental findings on the Parkinson's Disease Progression Markers Initiative data set that feature fusion may improve classification performance.

Alzheimer's disease (AD) is the main cause of dementia in the elderly. To date, it remains largely unknown whether and how dynamic characteristics of the functional networks differ from cognitively normal (CN) to AD. Here, we propose an AD dynamic network complexity intelligent detecting algorithm based on visibility graph. The focal regions that caused the dynamic abnormality of the connection mode were intelligently detected by creating a dynamic complexity network on the basis of the dynamic functional network. The results showed that the brain areas with different dynamic complexity gradually shifted from the frontal lobe to the temporal lobe and the occipital lobe. This was significantly related to the disorder of clinical patients from mood to memory and language. The increased dynamic complexity illustrates the compensatory effect of the brain area of AD lesions. In addition, the small-world topological properties of the dynamic complexity network have significant differences from CN to AD. To the best of our knowledge, this is the first time that such a concept is proposed. Our method of intelligently detecting the complexity of AD dynamic network provides new insights for understanding the internal dynamic mechanism of AD brain.