In an era of heightened digital interconnectedness, businesses increasingly rely on third-party vendors to enhance their operational capabilities. However, this growing dependency introduces significant security risks, making it crucial to develop a robust framework to mitigate potential vulnerabilities. This paper proposes a comprehensive secure framework for managing third-party vendor risk, integrating blockchain technology to ensure transparency, traceability, and immutability in vendor assessments and interactions. By leveraging blockchain, the framework enhances the integrity of vendor security audits, ensuring that vendor assessments remain up-to-date and tamperproof. This proposed framework leverages smart contracts to reduce human error while ensuring real-time monitoring of compliance and security controls. By evaluating critical security controls—such as data encryption, access control mechanisms, multi-factor authentication, and zero-trust architecture—this approach strengthens an organization’s defense against emerging cyber threats. Additionally, continuous monitoring enabled by blockchain ensures the immutability and transparency of vendor compliance processes. In this paper, a case study on iHealth’s transition to AWS Cloud demonstrates the practical implementation of the framework, showing a significant reduction in vulnerabilities and marked improvement in incident response times. Through the adoption of this blockchain-enabled approach, organizations can mitigate vendor risks, streamline compliance, and enhance their overall security posture. Our findings highlight the importance of employing blockchain to enforce security controls and maintain compliance with healthcare regulations such as HIPAA. In this paper, we present a comprehensive set of security controls and demonstrate how blockchain technology enhances their effectiveness, ensuring greater transparency, accountability, and automation in vendor assessments. By reducing human error, enabling real-time monitoring, and validating compliance, blockchain strengthens the overall security and resilience of the third-party vendor ecosystem.