This study introduces an innovative explainable AI (XAI) pipeline designed to predict breast cancer survival by integrating clinical, socioeconomic, and geographic data. Using data from 10,172 patients treated at hospitals in the Memphis, Tennessee metropolitan area, the pipeline identifies key survival determinants and reveals significant survival disparities affecting Black women. Advanced machine learning models combined with SHapley Additive exPlanations (SHAP) provide actionable and interpretable insights into the role of tumor stage, socioeconomic conditions, and access to preventive care. This framework facilitates personalized survival predictions and targeted equity-focused interventions, demonstrating the potential of multi-source data integration to address health inequities and improve patient outcomes.

This study reports on the progress in designing and developing a framework for integrating heterogeneous datasets—structured, semi-structured, and unstructured—into an AI-ready multimodal data pipeline aimed at predicting radiation therapy interruptions (RTI) and enhancing patient care navigation. The AI-Ready dataset incorporates a broad set of information, including patient demographics, health data, clinical notes, medical imaging, and data on social determinants of health. Preliminary results indicate that this pipeline effectively integrates diverse distributed data sources, providing a foundation for training AI models capable of generating reliable and actionable predictions.