Predicting survival outcomes for non-small cell lung cancer (NSCLC) patients is challenging due to the different individual prognostic features. This task can benefit from the integration of whole-slide images, bulk transcriptomics, and DNA methylation, which offer complementary views of the patient's condition at diagnosis. However, real-world clinical datasets are often incomplete, with entire modalities missing for a significant fraction of patients. State-of-the-art models rely on available data to create patient-level representations or use generative models to infer missing modalities, but they lack robustness in cases of severe missingness. We propose a Multimodal Contrastive Variational AutoEncoder (MCVAE) to address this issue: modality-specific variational encoders capture the uncertainty in each data source, and a fusion bottleneck with learned gating mechanisms is introduced to normalize the contributions from present modalities. We propose a multi-task objective that combines survival loss and reconstruction loss to regularize patient representations, along with a cross-modal contrastive loss that enforces cross-modal alignment in the latent space. During training, we apply stochastic modality masking to improve the robustness to arbitrary missingness patterns. Extensive evaluations on the TCGA-LUAD ($n=475$) and TCGA-LUSC ($n=446$) datasets demonstrate the efficacy of our approach in predicting disease-specific survival (DSS) and its robustness to severe missingness scenarios compared to two state-of-the-art models. Finally, we bring some clarifications on multimodal integration by testing our model on all subsets of modalities, finding that integration is not always beneficial to the task.

In online marketing, the advertisers aim to balance achieving high volumes and high profitability. The companies' business units address this tradeoff by maximizing the volumes while guaranteeing a minimum Return On Investment (ROI) level. Such a task can be naturally modeled as a combinatorial optimization problem subject to ROI and budget constraints that can be solved online. In this picture, the learner's uncertainty over the constraints' parameters plays a crucial role since the algorithms' exploration choices might lead to their violation during the entire learning process. Such violations represent a major obstacle to adopting online techniques in real-world applications. Thus, controlling the algorithms' exploration during learning is paramount to making humans trust online learning tools. This paper studies the nature of both optimization and learning problems. In particular, we show that the learning problem is inapproximable within any factor (unless P = NP) and provide a pseudo-polynomial-time algorithm to solve its discretized version. Subsequently, we prove that no online learning algorithm can violate the (ROI or budget) constraints a sublinear number of times during the learning process while guaranteeing a sublinear regret. We provide the GCB algorithm that guarantees sublinear regret at the cost of a linear number of constraint violations and GCBsafe that guarantees w.h.p.a constant upper bound on the number of constraint violations at the cost of a linear regret. Moreover, we designed GCBsafe(ψ, φ), which guarantees both sublinear regret and safety w.h.p. at the cost of accepting tolerances ψ and φ in the satisfaction of the ROI and budget constraints, respectively. Finally, we provide experimental results to compare the regret and constraint violations of GCB, GCBsafe, and GCBsafe(ψ, φ).

In several e-commerce scenarios, pricing long-tail products effectively is a central task for the companies, and there is broad agreement that Artificial Intelligence (AI) will play a prominent role in doing that in the next future. Nevertheless, dealing with long-tail products raises major open technical issues due to data scarcity which preclude the adoption of the mainstream approaches requiring usually a huge amount of data, such as, e.g., deep learning. In this paper, we provide a novel online learning algorithm for dynamic pricing that deals with non-stationary settings due to, e.g., the seasonality or adaptive competitors, and is very efficient in terms of the need for data thanks to assumptions such as, e.g., the monotonicity of the demand curve in the price that are customarily satisfied in long-tail markets. Furthermore, our dynamic pricing algorithm is paired with a clustering algorithm for the long-tail products which aggregates similar products such that the data of all the products of the same cluster are merged and used to choose their best price. We first evaluate our algorithms in an offline synthetic setting, comparing their performance with the state of the art and showing that our algorithms are more robust and data-efficient in long-tail settings. Subsequently, we evaluate our algorithms in an online setting with more than 8,000 products, including popular and long-tail, in an A/B test with humans for about two months. The increase of revenue thanks to our algorithms is about 18% for the popular products and about 90% for the long-tail products.

In 2017, Internet ad spending reached 209 billion USD worldwide, while, e.g., TV ads brought in 178 billion USD. An Internet advertising campaign includes up to thousands of sub-campaigns on multiple channels, e.g., search, social, display, whose parameters (bid and daily budget) need to be optimized every day, subject to a (cumulative) budget constraint. Such a process is often unaffordable for humans and its automation is crucial. As also shown by marketing funnel models, the sub-campaigns are usually interdependent, e.g., display ads induce awareness, increasing the number of impressions-and, thus, also the number of conversions-of search ads. This interdependence is widely exploited by humans in the optimization process, whereas, to the best of our knowledge, no algorithm takes it into account. In this paper, we provide the first model capturing the sub-campaigns interdependence. We also provide the IDIL algorithm, which, employing Granger Causality and Gaussian Processes, learns from past data, and returns an optimal stationary bid/daily budget allocation. We prove theoretical guarantees on the loss of IDIL w.r.t. the clairvoyant solution, and we show empirical evidence of its superiority in both realistic and real-world settings when compared with existing approaches.