False arrhythmia alarms in intensive care units (ICUs) are a continuing problem despite considerable effort from industrial and academic algorithm developers. Of all life-threatening arrhythmias, ventricular tachycardia (VT) stands out as the most challenging arrhythmia to detect reliably. We introduce a new annotated VT alarm database, VTaC (Ventricular Tachycardia annotated alarms from ICUs) consisting of over 5,000 waveform recordings with VT alarms triggered by bedside monitors in the ICU. Each VT alarm waveform in the dataset has been labeled by at least two independent human expert annotators. The dataset encompasses data collected from ICUs in two major US hospitals and includes data from three leading bedside monitor manufacturers, providing a diverse and representative collection of alarm waveform data. Each waveform recording comprises at least two electrocardiogram (ECG) leads and one or more pulsatile waveforms, such as photoplethysmogram (PPG or PLETH) and arterial blood pressure (ABP) waveforms. We demonstrate the utility of this new benchmark dataset for the task of false arrhythmia alarm reduction, and present performance of multiple machine learning approaches, including conventional supervised machine learning, deep learning, semi-supervised learning, and generative approaches for the task of VT false alarm reduction.

Post-Traumatic Stress Disorder (PTSD) is a psychiatric condition resulting from threatening or horrifying events. We hypothesized that circadian rhythm changes, measured by a wrist-worn research watch are predictive of post-trauma outcomes. APPROACH: 1618 post-trauma patients were enrolled after admission to emergency departments (ED). Three standardized questionnaires were administered at week eight to measure post-trauma outcomes related to PTSD, sleep disturbance, and pain interference with daily life. Pulse activity and movement data were captured from a research watch for eight weeks. Standard and novel movement and cardiovascular metrics that reflect circadian rhythms were derived using this data. These features were used to train different classifiers to predict the three outcomes derived from week-eight surveys. Clinical surveys administered at ED were also used as features in the baseline models. RESULTS: The highest cross-validated performance of research watch-based features was achieved for classifying participants with pain interference by a logistic regression model, with an area under the receiver operating characteristic curve (AUC) of 0.70. The ED survey-based model achieved an AUC of 0.77, and the fusion of research watch and ED survey metrics improved the AUC to 0.79. SIGNIFICANCE: This work represents the first attempt to predict and classify post-trauma symptoms from passive wearable data using machine learning approaches that leverage the circadian desynchrony in a potential PTSD population.