We integrated two simulators, a Virtual Patient (VP) system and a physical Human Patient Simulator (HPS) to create a mixed reality conscious sedation training environment. The VP system simulates clinical environments where learners conduct patient interviews. The HPS is a mannequin that models and simulates a wide array of clinical signs. The VP+HPS combination provides new capabilities specially suited for conscious sedation training. Future work will evaluate the efficacy of this MR simulation.