Automated program repair (APR) has been gaining ground recently. However, a significant challenge that still remains is test overfitting, in which APR-generated patches plausibly pass the validation test suite but fail to generalize. A common practice to assess the correctness of APR-generated patches is to judge whether they are equivalent to ground truth, i.e., developer-written patches, by either generating additional test cases or employing human manual inspections. The former often requires the generation of at least one test that shows behavioral differences between the APR-patched and developer-patched programs. Searching for this test, however, can be difficult as the search space can be enormous. Meanwhile, the latter is prone to human biases and requires repetitive and expensive manual effort. In this paper, we propose a novel technique,Invalidator, to automatically assess the correctness of APR-generated patches via semantic and syntactic reasoning.Invalidatorleverages program invariants to reason about program semantics while also capturing program syntax through language semantics learned from a large code corpus using a pre-trained language model. Given a buggy program and the developer-patched program,Invalidatorinfers likely invariants on both programs. Then,Invalidatordetermines that an APR-generated patch overfits if: (1) it violates correct specifications or (2) maintains erroneous behaviors from the original buggy program. In case our approach fails to determine an overfitting patch based on invariants,Invalidatorutilizes a trained model from labeled patches to assess patch correctness based on program syntax. The benefit ofInvalidatoris threefold. First,Invalidatorleverages both semantic and syntactic reasoning to enhance its discriminative capability. Second,Invalidatordoes not require new test cases to be generated, but instead only relies on the current test suite and uses invariant inference to generalize program behaviors. Third,Invalidatoris fully automated. We conducted our experiments on a dataset of 885 patches generated on real-world programs in Defects4J. Experiment results show thatInvalidatorcorrectly classified 79% of overfitting patches, accounting for 23% more overfitting patches being detected than the best baseline.Invalidatoralso substantially outperforms the best baselines by 14% and 19% in terms of Accuracy and F-Measure, respectively.