Epidemiological studies comprise heterogeneous data about a subject group to define disease-specific risk factors. These data contain information (features) about a subject's lifestyle, medical status as well as medical image data. Statistical regression analysis is used to evaluate these features and to identify feature combinations indicating a disease (the target feature). We propose an analysis approach of epidemiological data sets by incorporating all features in an exhaustive regression-based analysis. This approach combines all independent features w.r.t. a target feature. It provides a visualization that reveals insights into the data by highlighting relationships. The 3D Regression Heat Map, a novel 3D visual encoding, acts as an overview of the whole data set. It shows all combinations of two to three independent features with a specific target disease. Slicing through the 3D Regression Heat Map allows for the detailed analysis of the underlying relationships. Expert knowledge about disease-specific hypotheses can be included into the analysis by adjusting the regression model formulas. Furthermore, the influences of features can be assessed using a difference view comparing different calculation results. We applied our 3D Regression Heat Map method to a hepatic steatosis data set to reproduce results from a data mining-driven analysis. A qualitative analysis was conducted on a breast density data set. We were able to derive new hypotheses about relations between breast density and breast lesions with breast cancer. With the 3D Regression Heat Map, we present a visual overview of epidemiological data that allows for the first time an interactive regression-based analysis of large feature sets with respect to a disease.

Epidemiological population studies impose information about a set of subjects (a cohort) to characterize disease-specific risk factors. Cohort studies comprise heterogenous variables describing the medical condition as well as demographic and lifestyle factors and, more recently, medical image data. We propose an Interactive Visual Analysis (IVA) approach that enables epidemiologists to rapidly investigate the entire data pool for hypothesis validation and generation. We incorporate image data, which involves shape-based object detection and the derivation of attributes describing the object shape. The concurrent investigation of image-based and non-image data is realized in a web-based multiple coordinated view system, comprising standard views from information visualization and epidemiological data representations such as pivot tables. The views are equipped with brushing facilities and augmented by 3D shape renderings of the segmented objects, e.g., each bar in a histogram is overlaid with a mean shape of the associated subgroup of the cohort. We integrate an overview visualization, clustering of variables and object shape for data-driven subgroup definition and statistical key figures for measuring the association between variables. We demonstrate the IVA approach by validating and generating hypotheses related to lower back pain as part of a qualitative evaluation.