Depression is a serious mood disorder that has become one of the major diseases that endanger human mental health.The automatic detection of depression using speech signals has become a promising approach for the early diagnosis of depression currently.However, there is still a performance gap between clinical practice and research, considering the labrecorded corpus was used in most of the current studies.Therefore, we collected a Chinese clinical depression corpus, of which 131 participants with their speech during the Hamilton Rating Scale for Depression (HAMD) interview were included in this study.Furthermore, we developed a depression speech detection system based on a Time-Delay Neural Network (TDNN) model to distinguish depression i .Our approach achieves a mean F1 score of 90.8% and an accuracy of 90.4% by five-fold cross-validation.The result suggests that the developed TDNN-based model has a potential clinical meaning in the diagnosis of depression.