Likely drug candidates which are identified in traditional pre-clinical drug screens often fail in patient trials, increasing the societal burden of drug discovery. A major contributing factor to this phenomenon is the failure of traditional in vitro models of drug response to accurately mimic many of the more complex properties of human biology. We have recently introduced a new microphysiological system for growing vascularized, perfused microtissues that more accurately models human physiology and is suitable for large drug screens. In this work, we develop a machine learning model that can quickly and accurately flag compounds which effectively disrupt vascular networks from images taken before and after drug application in vitro. The system is based on a convolutional neural network and achieves near perfect accuracy while committing potentially no expensive false negatives.

Quantitative notions of diversity have been explored across a variety of disciplines ranging from conservation biology to economics. However, there has been relatively little work on measuring the diversity of text documents via their content. In this paper we present a text-based framework for quantifying how diverse a document is in terms of its content. The proposed approach learns a topic model over a corpus of documents, and computes a distance matrix between pairs of topics using measures such as topic co-occurrence. These pairwise distance measures are then combined with the distribution of topics within a document to estimate each document's diversity relative to the rest of the corpus. The method provides several advantages over existing methods. It is fully data-driven, requiring only the text from a corpus of documents as input, it produces human-readable explanations, and it can be generalized to score diversity of other entities such as authors, academic departments, or journals. We describe experimental results on several large data sets which suggest that the approach is effective and accurate in quantifying how diverse a document is relative to other documents in a corpus.