Accurate compensation of brain deformation is critical for reliable image-guided neurosurgery. Surgical manipulation and tumor resection induce tissue motion, causing preoperative planning images to become misaligned with the intraoperative anatomy. In this review, we examine data-driven methods developed between 2020 and 2025 for brain deformation registration and modeling, with a particular focus on learning-based approaches. A comprehensive literature search was conducted in PubMed, IEEE Xplore, Scopus, and Web of Science using predefined inclusion and exclusion criteria for computational methods addressing brain deformation in neurosurgical imaging, resulting in 46 eligible studies. We provide a unified analysis of methodological strategies, including deep learning-based image registration, direct deformation field regression, synthesis-driven multimodal alignment, resection-aware architectures for handling missing correspondences, and hybrid models integrating biomechanical priors. We also examine dataset utilization, evaluation metrics, validation protocols, and the assessment of uncertainty and generalization across studies. While learning-based methods demonstrate promising accuracy and computational efficiency, current approaches remain limited by out-of-distribution robustness, standardized benchmarking, interpretability, and readiness for clinical deployment. Our review highlights these gaps and outlines future directions toward more robust, generalizable, and clinically translatable solutions for neurosurgical guidance. By organizing recent advances and critically assessing evaluation practices, this work provides a comprehensive reference for researchers and clinicians working on data-driven registration and modeling of brain deformation.

In this work, we address the problem of learning an ensemble of specialist networks using multimodal data, while considering the realistic and challenging scenario of possible missing modalities at test time. Our goal is to leverage the complementary information of multiple modalities to the benefit of the ensemble and each individual network. We introduce a novel Distillation Multiple Choice Learning framework for multimodal data, where different modality networks learn in a cooperative setting from scratch, strengthening one another. The modality networks learned using our method achieve significantly higher accuracy than if trained separately, due to the guidance of other modalities. We evaluate this approach on three video action recognition benchmark datasets. We obtain state-of-the-art results in comparison to other approaches that work with missing modalities at test time.

Heterogeneous data modalities can provide complementary cues for several tasks, usually leading to more robust algorithms and better performance. However, while training data can be accurately collected to include a variety of sensory modalities, it is often the case that not all of them are available in real life (testing) scenarios, where a model has to be deployed. This raises the challenge of how to extract information from multimodal data in the training stage, in a form that can be exploited at test time, considering limitations such as noisy or missing modalities. This paper presents a new approach in this direction for RGB-D vision tasks, developed within the adversarial learning and privileged information frameworks. We consider the practical case of learning representations from depth and RGB videos, while relying only on RGB data at test time. We propose a new approach to train a hallucination network that learns to distill depth information via adversarial learning, resulting in a clean approach without several losses to balance or hyperparameters. We report state-of-the-art results for object classification on the NYUD dataset, and video action recognition on the largest multimodal dataset available for this task, the NTU RGB+D, as well as on the Northwestern-UCLA.

This paper describes Metabolic.Care, a sub-project that integrates hardware and software with the main goal of implementing a solution that generates warnings for the diagnosis on patients with diabetic foot. This paper also describes the adopted strategies and best practices found to solve the problems.