Background: Looking pattern differences are shown to separate individuals with Autism Spectrum Disorder (ASD) and Typically Developing (TD) controls. Recent studies have shown that, in children with ASD, these patterns change with intellectual and social impairments, suggesting that patterns of social attention provide indices of clinically meaningful variation in ASD. Method: We conducted a naturalistic study of children with ASD (n = 55) and typical development (TD, n = 32). A battery of eye-tracking video stimuli was used in the study, including Activity Monitoring (AM), Social Referencing (SR), Theory of Mind (ToM), and Dyadic Bid (DB) tasks. This work reports on the feasibility of spatial and spatiotemporal scanpaths generated from eye-gaze patterns of these paradigms in stratifying ASD and TD groups. Algorithm: This article presents an approach for automatically identifying clinically meaningful information contained within the raw eye-tracking data of children with ASD and TD. The proposed mechanism utilizes combinations of eye-gaze scan-paths (spatial information), fused with temporal information and pupil velocity data and Convolutional Neural Network (CNN) for stratification of diagnosis (ASD or TD). Results: Spatial eye-gaze representations in the form of scanpaths in stratifying ASD and TD (ASD vs. TD: DNN: 74.4%) are feasible. These spatial eye-gaze features, e.g., scan-paths, are shown to be sensitive to factors mediating heterogeneity in ASD: age (ASD: 2–4 y/old vs. 10–17 y/old CNN: 80.5%), gender (Male vs. Female ASD: DNN: 78.0%) and the mixture of age and gender (5–9 y/old Male vs. 5–9 y/old Female ASD: DNN:98.8%). Limiting scan-path representations temporally increased variance in stratification performance, attesting to the importance of the temporal dimension of eye-gaze data. Spatio-Temporal scan-paths that incorporate velocity of eye movement in their images of eye-gaze are shown to outperform other feature representation methods achieving classification accuracy of 80.25%. Conclusion: The results indicate the feasibility of scan-path images to stratify ASD and TD diagnosis in children of varying ages and gender. Infusion of temporal information and velocity data improves the classification performance of our deep learning models. Such novel velocity fused spatio-temporal scan-path features are shown to be able to capture eye gaze patterns that reflect age, gender, and the mixed effect of age and gender, factors that are associated with heterogeneity in ASD and difficulty in identifying robust biomarkers for ASD.

Gaze calibration is common in traditional infrared oculographic eye tracking. However, it is not well studied in visible-light mobile/remote eye tracking. We developed a lightweight real-time gaze error estimator and analyzed calibration errors from two perspectives: facial feature-based and Monte Carlo-based. Both methods correlated with gaze estimation errors, but the Monte Carlo method associated more strongly. Facial feature associations with gaze error were interpretable, relating movements of the face to the visibility of the eye. We highlight the degradation of gaze estimation quality in a sample of children with autism spectrum disorder (as compared to typical adults), and note that calibration methods may improve Euclidean error by 10%.

Identifying oculomotor behaviors relevant for eye-tracking applications is a critical but often challenging task. Aiming to automatically learn and extract knowledge from existing eye-tracking data, we develop a novel method that creates rich representations of oculomotor scanpaths to facilitate the learning of downstream tasks. The proposed stimulus-agnostic Oculomotor Behavior Framework (OBF) model learns human oculomotor behaviors from unsupervised and semi-supervised tasks, including reconstruction, predictive coding, fixation identification, and contrastive learning tasks. The resultant pre-trained OBF model can be used in a variety of applications. Our pre-trained model outperforms baseline approaches and traditional scanpath methods in autism spectrum disorder and viewed-stimulus classification tasks. Ablation experiments further show our proposed method could achieve even better results with larger model sizes and more diverse eye-tracking training datasets, supporting the model’s potential for future eye-tracking applications. Open source code: http://github.com/BeibinLi/OBF.

In this paper, we introduce an end-to-end machine learning-based system for classifying autism spectrum disorder (ASD) using facial attributes such as expressions, action units, arousal, and valence. Our system classifies ASD using representations of different facial attributes from convolutional neural networks, which are trained on images in the wild. Our experimental results show that different facial attributes used in our system are statistically significant and improve sensitivity, specificity, and F1 score of ASD classification by a large margin. In particular, the addition of different facial attributes improves the performance of ASD classification by about 7% which achieves a F1 score of 76%.

Far infrared thermography, which can be used to detect thermal radiation emitted by humans, has been used to detect physical disease, physiological changes relating to emotion, and polygraph testing, but has not been used for eye tracking. However, because the surface temperature of the cornea is colder than the limbus, it is theoretically possible to track corneal movements through thermal imaging. To explore the feasibility of thermal eye tracking, we invited 10 adults and tracked their corneal movements with passive thermal imaging at 60 Hz. We combined shape models of eyes with intensity threshold to segment the cornea from other parts of the eye in thermal images. We used an animation sequence as a calibration target for 5 point calibration/validation 5 times. Our results were compared to simultaneously collected data using an SR EyeLink eye tracker at 500 Hz, demonstrating the feasibility of eye tracking with thermal images. Blinking and breathing frequencies, which reflect the psychophysical status of the participants, were also robustly detected during thermal eye tracking.

Robots are often employed to proactively engage children with Autism Spectrum Disorder (ASD) in well-defined physical or social activities to promote specific educational or therapeutic outcomes. However, much can also be learned by leveraging a robot's unique ability to objectively deliver stimuli in a consistent, repeatable way and record child-robot interactions that may be indicative of developmental ability and autism severity in this population. In this study, we elicited affective responses with an emotion-simulating robot and recorded child-robot interactions and child-other interactions during robot emotion states. This research makes two key contributions. First, we analyzed child-robot interactions and affective responses to an emotion-simulating robot to explore differences between the responses of typically developing children and children with Autism Spectrum Disorder (ASD). Next, we characterized play and affective responsivity and its connection to severity of autism symptoms using the Autism Diagnostic Observation Schedule (ADOS) calibrated severity scores. This preliminary work delivers a novel and robust robot-enabled technique for (1) differentiating child-robot interactions of a group of very young children with ASD (n=12) from a group of typically developing children (n=15) and, (2) characterizing within-group differences in play and affective response that may be associated with symptoms of autism severity.

In their expanding role as tutors, home and healthcare assistants, robots must effectively interact with individuals of varying ability and temperament. Indeed, deploying robots in long-term social engagements will almost certainly require robots to reliably detect and adapt to changes in the demeanor of social partners to promote trust and more productive collaboration. However, the recognition of emotional state typically relies on the interpretation of very subtle cues, often varying from one person to the next. In addition, while facial expressions, body posture and features of speech have been used to detect affective changes, the robustness of these measures is often hindered by cultural and age differences. Recently, infrared thermography has shown promise in detecting guilt, fear and stress, indicating that it may be a viable sensing modality for improved human-robot interaction. In this study, we evaluated the efficacy of using a far infrared (FIR) camera for detecting robot-elicited affective response compared to video-elicited affective response by tracking thermal changes in five areas of the face. Further, we analyzed localized changes in the face to assess whether thermal and electrodermal responses to emotions elicited by traditional video techniques and by robots are similar. Finally, we performed principal component analysis to reduce the dimensionality of data and evaluated the performance using machine learning techniques for classifying thermal data by emotion state, resulting in a thermal classifier with a performance accuracy of 77.5%.