The limited depth of field of optical lenses, makes multi-focus image fusion (MFIF) algorithms of vital importance. Lately, Convolutional Neural Networks (CNN) have been widely adopted in MFIF methods, however their predictions mostly lack structure and are limited by the size of the receptive field. Moreover, since images have noise due to various sources, the development of MFIF methods robust to image noise is required. A novel robust to noise Convolutional Neural Network-based Conditional Random Field (mf-CNNCRF) model is introduced. The model takes advantage of the powerful mapping between input and output of CNN networks and the long range interactions of the CRF models in order to reach structured inference. Rich priors for both unary and smoothness terms are learned by training CNN networks. The α -expansion graph-cut algorithm is used to reach structured inference for MFIF. A new dataset, which includes clean and noisy image pairs, is introduced and is used to train the networks of both CRF terms. A low-light MFIF dataset is also developed to demonstrate real-life noise introduced by the camera sensor. Qualitative and quantitative evaluation prove that mf-CNNCRF outperforms state-of-the-art MFIF methods for clean and noisy input images, while being more robust to different noise types without requiring prior knowledge of noise.

In this paper, a novel multi-focus image fusion algorithm based on conditional random field optimization (mf-CRF) is proposed. It is based on an unary term that includes the combined activity estimation of both high and low frequencies of the input images, while a spatially varying smoothness term is introduced, in order to align the graph-cut solution with boundaries of focused and defocused pixels. The proposed model retains the advantages of both spatial-domain methods and multi-spectral methods and by solving an energy minimization problem and finds an optimal solution for the multi-focus image fusion problem. Experimental results demonstrate the effectiveness of the proposed method that outperforms current state-of-the-art multi-focus image fusion algorithms in both qualitative and quantitative comparisons. In this paper, the successful application of the mf-CRF model in multi-modal image fusion (visible-infrared and medical) is also presented.