Cohort studies are of significant importance in the field of healthcare analytics. However, existing methods typically involve manual, labor-intensive, and expert-driven pattern definitions or rely on simplistic clustering techniques that lack medical relevance. Automating cohort studies with interpretable patterns has great potential to facilitate healthcare analytics and data management but remains an unmet need in prior research efforts. In this paper, we present a cohort auto-discovery framework for interpretable healthcare analytics. It focuses on the effective identification, representation, and exploitation of cohorts characterized by medically meaningful patterns. In the framework, we propose CohortNet, a core model that can learn fine-grained patient representations by separately processing each feature, considering both individual feature trends and feature interactions at each time step. Subsequently, it employs K-Means in an adaptive manner to classify each feature into distinct states and a heuristic cohort exploration strategy to effectively discover substantial cohorts with concrete patterns. For each identified cohort, it learns comprehensive cohort representations with credible evidence through associated patient retrieval. Ultimately, given a new patient, CohortNet can leverage relevant cohorts with distinguished importance which can provide a more holistic understanding of the patient's conditions. Extensive experiments on three real-world datasets demonstrate that it consistently outperforms state-of-the-art approaches, resulting in improvements in AUC-PR scores ranging from 2.8% to 4.1%, and offers interpretable insights from diverse perspectives in a top-down fashion.

Data processing and analytics are fundamental and pervasive. Algorithms play a vital role in data processing and analytics where many algorithm designs have incorporated heuristics and general rules from human knowledge and experience to improve their effectiveness. Recently, reinforcement learning, deep reinforcement learning (DRL) in particular, is increasingly explored and exploited in many areas because it can learn better strategies in complicated environments it is interacting with than statically designed algorithms. Motivated by this trend, we provide a comprehensive review of recent works focusing on utilizing deep reinforcement learning to improve data processing and analytics. First, we present an introduction to key concepts, theories, and methods in deep reinforcement learning. Next, we discuss deep reinforcement learning deployment on database systems, facilitating data processing and analytics in various aspects, including data organization, scheduling, tuning, and indexing. Then, we survey the application of deep reinforcement learning in data processing and analytics, ranging from data preparation, natural language interface to healthcare, fintech, etc. Finally, we discuss important open challenges and future research directions of using deep reinforcement learning in data processing and analytics.

Text-based image captioning (TextCap) requires simultaneous comprehension of visual content and reading the text of images to generate a natural language description. Although a task can teach machines to understand the complex human environment further given that text is omnipresent in our daily surroundings, it poses additional challenges in normal captioning. A text-based image intuitively contains abundant and complex multimodal relational content, that is, image details can be described diversely from multiview rather than a single caption. Certainly, we can introduce additional paired training data to show the diversity of images' descriptions, this process is labor-intensive and time-consuming for TextCap pair annotations with extra texts. Based on the insight mentioned above, we investigate how to generate diverse captions that focus on different image parts using an unpaired training paradigm. We propose the Multimodal relAtional Graph adversarIal InferenCe (MAGIC) framework for diverse and unpaired TextCap. This framework can adaptively construct multiple multimodal relational graphs of images and model complex relationships among graphs to represent descriptive diversity. Moreover, a cascaded generative adversarial network is developed from modeled graphs to infer the unpaired caption generation in image–sentence feature alignment and linguistic coherence levels. We validate the effectiveness of MAGIC in generating diverse captions from different relational information items of an image. Experimental results show that MAGIC can generate very promising outcomes without using any image–caption training pairs.

In this paper, we propose a novel semi-supervised learning (SSL) framework named BoostMIS that combines adaptive pseudo labeling and informative active annotation to unleash the potential of medical image SSL models: (1) BoostMIS can adaptively leverage the cluster assumption and consistency regularization of the unlabeled data according to the current learning status. This strategy can adaptively generate one-hot “hard” labels converted from task model predictions for better task model training. (2) For the unselected unlabeled images with low confidence, we introduce an Active learning (AL) algorithm to find the informative samples as the annotation candidates by exploiting virtual adversarial perturbation and model's density-aware entropy. These informative candidates are subsequently fed into the next training cycle for better SSL label propagation. Notably, the adaptive pseudo-labeling and informative active annotation form a learning closed-loop that are mutually collaborative to boost medical image SSL. To verify the effectiveness of the proposed method, we collected a metastatic epidural spinal cord compression (MESCC) dataset that aims to optimize MESCC diagnosis and classification for improved specialist referral and treatment. We conducted an extensive experimental study of BoostMIS on MESCC dataset. The experimental results verify our framework's effectiveness with a significant improvement over various state-of-the-art methods. Our work will be available at github11https://github.com/wannature/BoostMIS.

Interaction learning plays an essential role in learning patients' comprehensive representations that contribute to improved performance in many analytical tasks. In healthcare, interactions among medical features (i.e., feature-level interactions) can exhibit different abnormal patterns in detail, while interactions among time steps (i.e., time-level interactions) can indicate the dynamic changes in patients' health conditions. Therefore, it is necessary to capture and analyze both types of interactions when conducting healthcare analytics, In this paper, we propose a general framework ELDA that is supported by the novel model ELDA-Net to learn dual-interactions for healthcare analytics in an explicit manner. Specifically, we devise a Feature-level Interaction Learning Module that can enrich a separately processed medical feature by learned interactions among medical features, and a Time-level Interaction Learning Module that can enhance the representations of the patients' health conditions by learned interactions among time steps. In both levels, ELDA can provide explicit and intuitive interpretations via explaining through the designed attention mechanism. Further, to facilitate the feature-level interaction learning, we propose a novel Bi-directional Embedding Module in ELDA-Net which can efficiently embed the medical features recorded in numerical values. We evaluate the effectiveness and interpretability of ELDA over two public real-world clinical datasets. The experimental results confirm that ELDA consistently outperforms existing state-of-the-art methods with a significant margin, and supports fine-grained interpretability in both the feature level and the time level with medical insights.