Numerous experimental studies have indicated that alteration and dysregulation in mircroRNAs (miRNAs) are associated with serious diseases. Identifying disease-related miRNAs is therefore an essential and challenging task in bioinformatics research. Computational methods are an efficient and economical alternative to conventional biomedical studies and can reveal underlying miRNA-disease associations for subsequent experimental confirmation with reasonable confidence. Despite the success of existing computational approaches, most of them only rely on the known miRNA-disease associations to predict associations without adding other data to increase the prediction accuracy, and they are affected by issues of data sparsity. In this paper, we present MRRN, a model that combines matrix reconstruction with node reliability to predict probable miRNA-disease associations. In MRRN, the most reliable neighbors of miRNA and disease are used to update the original miRNA-disease association matrix, which significantly reduces data sparsity. Unknown miRNA-disease associations are reconstructed by aggregating the most reliable first-order neighbors to increase prediction accuracy by representing the local and global structure of the heterogeneous network. Five-fold cross-validation of MRRN produced an area under the curve (AUC) of 0.9355 and area under the precision-recall curve (AUPR) of 0.2646, values that were greater than those produced by comparable models. Two different types of case studies using three diseases were conducted to demonstrate the accuracy of MRRN, and all top 30 predicted miRNAs were verified.

Soft magnetic miniature robots (SMMRs) have potential biomedical applications due to their flexible size and mobility to access confined environments. However, navigating the robot to a goal site with precise control performance and high repeatability in unstructured environments, especially in flow rate conditions, still remains a challenge. In this study, drawing inspiration from the control requirements of drug delivery and release to the goal lesion site in the presence of dynamic biofluids, we propose a flow rate rejection control strategy based on a deep reinforcement learning (DRL) framework to actuate an SMMR to achieve goal-reaching and hovering in fluidic tubes. To this end, an SMMR is first fabricated, which can be operated by an external magnetic field to realize its desired functionalities. Subsequently, a simulator is constructed based on neural networks to map the relationship between the applied magnetic field and robot locomotion states. With minimal prior knowledge about the environment and dynamics, a gated recurrent unit (GRU)-based DRL algorithm is formulated by considering the designed history state-action and estimated flow rates. In addition, the randomization technique is applied during training to distill the general control policy for the physical SMMR. The results of numerical simulations and experiments are illustrated to demonstrate the robustness and efficacy of the presented control framework. Finally, in-depth analyses and discussions indicate the potentiality of DRL for soft magnetic robots in biomedical applications.

After years of development, various swarms of robots have been proposed for many complicated tasks, such as forming patterns, cooperative locomotion, and adapting to different environments. However, controlling microrobotic swarms is still a challenging task owing to the lacking of integrated devices on the small-scale agents, and actuation of multiple microrobotic swarms to different targets under the same global input will be even more difficult. In this work, we present a swarm of nickel nanorods and its diverse locomotion velocity compared with Fe3O4nanoparticle swarms is implemented for actuating the two swarms to different targets under the same customized oscillating magnetic field. The effects of the magnetic anisotropy of agents on the macroscopic swarm behaviour are analysed theoretically. To prove the strategy, the speeds of the two swarms were characterized through experiments, and demonstrations were conducted to show the capability of driving the two swarms to different locations in the same environment. Furthermore, parallel locomotion of the two swarms towards opposite directions was also achieved on a tilted substrate. This work has proved the feasibility of simultaneously actuating two swarms to diverse targets and promoted fundamental understandings of microrobotic swarms.

In this paper, a novel magnetic manipulation system using mobile coils for remote actuation of magnetic untethered devices in an enlarged workspace is proposed and studied. A parallel mechanism is implemented to actuate the mobile coils. A proof-of-concept prototype is designed and constructed, namely the DeltaMag, which includes three electromagnetic coils for generating magnetic fields and three motors for actuation of the coils. It has good space utilization: ratio between the diameter of the workspace and the diameter of the whole prototype reaches 0.7.A calibrated mathematical model is developed for the field distribution of a single coil, which has an average error of 8.75%. Then, we introduce a calculation method for the 3D magnetic field at any working position for the configuration of multiple parallel mobile coils. Moreover, an embedded system is established for actuating the parallel mechanism, whose pose is fed back via serial communication for magnetic field computation. A vision based approach is developed for closed-loop control of the parallel mechanism. Furthermore, experiments demonstrate the capabilities of the DeltaMag for manipulation of a magnetic catheter mock-up and a magnetic capsule mock-up in a workspace with a diameter more than 200 mm.

Microrobots are considered as potential candidates for targeted delivery of cargos, drugs and even energy with high precision. One interesting phenomenon is their collective behaviour actuated by dynamic fields, which is yet to be adequately studied. Herein, we report a novel method of using millions of magnetic nanoparticles to generate a dynamic-equilibrium particle-based vortex, which can manipulate multiple cargos simultaneously at the microscale. The governing physical laws of the generation of a particle-based vortex are explained and the experimental results are presented. The high effectiveness of this micro-vortex-based method of particle gathering is testified. Moreover, the vortex can be navigated near a solid surface in a controlled manner. The velocity and morphology of the mobile vortices with different pitch angles are investigated, showing that the vortex moving with small pitch angles is capable of maintaining the original shape and coverage area. Collecting and transporting multiple polystyrene (PS) microbeads into a channel using the vortex are also demonstrated. This method allows us to perform micromanipulation using the collective behaviour of nanoparticles and to develop new strategies for the formation and control of the microrobotic swarm.