This letter describes the wave reflection induced by the breakwater of the Port of Civitavecchia in the Tyrrhenian Sea, Italy, using a$X$-band wave radar. The wave radar system detected a complex structure of reflected waves that is composed of three spectral components and was generated by the complex structure of the breakwater. By applying a filter in the$\omega - k$domain, it was possible to filter out the component of the incident waves to analyze the total component of reflected waves. Applying specific filters also made it possible to separate the spectral components of the single reflected waves. Bandpass filters were built to select each spectral component based on only the direction of the incident and reflected wave components. Starting from the separated spectral components, the reflection coefficients related to the measurement campaign were estimated and compared with the theoretical coefficients. The results confirm the potential of a radar system to resolve a complex sea state and provide a synoptic analysis of wave propagation processes over a wide measurement domain. Furthermore, this letter opens the way for new studies on the interaction between incident waves and coastal infrastructure.

MOTIVATION: A computational model equipped with the main immunological features of the sea bass (Dicentrarchus labrax L.) immune system was used to predict more effective vaccination in fish. The performance of the model was evaluated by using the results of two in vivo vaccinations trials against L. anguillarum and P. damselae. RESULTS: Tests were performed to select the appropriate doses of vaccine and infectious bacteria to set up the model. Simulation outputs were compared with the specific antibody production and the expression of BcR and TcR gene transcripts in spleen. The model has shown a good ability to be used in sea bass and could be implemented for different routes of vaccine administration even with more than two pathogens. The model confirms the suitability of in silico methods to optimize vaccine doses and the immune response to them. This model could be applied to other species to optimize the design of new vaccination treatments of fish in aquaculture. AVAILABILITY AND IMPLEMENTATION: The method is available at http://www.iac.cnr.it/∼filippo/c-immsim/. CONTACT: [email protected]. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.