Gradient-based methods are a prototypical family of "explainability for AI" (XAI) techniques, especially for image-based models. However, they (1) require white-box access to models, (2) are vulnerable to adversarial attacks, and (3) produce attributions that lie off the image manifold, leading to explanations that are not amenable to human perception. To overcome these challenges, we introduce Derivative-Free Diffusion Manifold-Contrained Gradients (FreeMCG): by leveraging ensemble Kalman filters and diffusion models, we derive a derivative-free approximation of the model’s gradient projected onto the data manifold, requiring access only to the model’s outputs (i.e., black-box setting). We demonstrate the effectiveness of FreeMCG by applying it to both counterfactual generation and feature attribution, which have traditionally been treated as different tasks requiring distinct methods. Through comprehensive evaluation on both counter-factual explanation and feature attribution we show that our method yields state-of-the-art results for both tasks while preserving the essential properties expected of XAI tools. Code: https://github.com/one-june/FreeMCG.

Following the impressive development of LLMs, vision-language alignment in LLMs is actively being researched to enable multimodal reasoning and visual input/output. This direction of research is particularly relevant to medical imaging because accurate medical image analysis and generation consist of a combination of reasoning based on visual features and prior knowledge. Many recent works have focused on training adapter networks that serve as an information bridge between image processing (encoding or generating) networks and LLMs; but presumably, in order to achieve maximum reasoning potential of LLMs on visual information as well, visual and language features should be allowed to interact more freely. This is especially important in the medical domain because understanding and generating medical images such as chest X-rays (CXR) require not only accurate visual and language-based reasoning but also a more intimate mapping between the two modalities. Thus, taking inspiration from previous work on the transformer and VQ-GAN combination for bidirectional image and text generation, we build upon this approach and develop a method for instruction-tuning an LLM pre-trained only on text to gain vision-language capabilities for medical images. Specifically, we leverage a pretrained LLM’s existing question-answering and instruction-following abilities to teach it to understand visual inputs by instructing it to answer questions about image inputs and, symmetrically, output both text and image responses appropriate to a given query by tuning the LLM with diverse tasks that encompass image-based text-generation and text-based image-generation. We show that our LLM-CXR trained in this approach shows better image-text alignment in both CXR understanding and generation tasks while being smaller in size compared to previously developed models that perform a narrower range of tasks.

In this paper, we derive a lower bound on the alphabet size of the optimal uncorrelated polyphase ZCZ sequence families, assuming that Mow’s Conjecture is true. We also propose some new optimal uncorrelated polyphase ZCZ sequence families for all the optimal ZCZ parameters. All our proposed families achieve our proposed alphabet size bound so that this bound is the minimum alphabet size (assuming Mow’s conjecture is true). We also derive some interesting facts regardless of the truth of Mow’s Conjecture: an optimal ZCZ family of normalized sequence (not necessarily uncorrelated) is always periodic complementary; therefore, a sequence generated by interleaving all the sequences in an optimal uncorrelated ZCZ family of normalized sequences is always a perfect sequence.