Signal processing, communications, and control have traditionally relied on classical statistical modeling techniques. Such model-based methods utilize mathematical formulations that represent the underlying physics, prior information, and additional domain knowledge. Simple classical models are useful but sensitive to inaccuracies and may lead to poor performance when real systems display complex or dynamic behavior. On the other hand, purely data-driven approaches that are model-agnostic are becoming increasingly popular as datasets become abundant and the power of modern deep learning pipelines increases. Deep neural networks (DNNs) use generic architectures that learn to operate from data and demonstrate excellent performance, especially for supervised problems. However, DNNs typically require massive amounts of data and immense computational resources, limiting their applicability for some scenarios. In this article, we present the leading approaches for studying and designing model-based deep learning systems. These are methods that combine principled mathematical models with data-driven systems to benefit from the advantages of both approaches. Such model-based deep learning methods exploit both partial domain knowledge, via mathematical structures designed for specific problems, and learning from limited data. Among the applications detailed in our examples for model-based deep learning are compressed sensing, digital communications, and tracking in state-space models. Our aim is to facilitate the design and study of future systems at the intersection of signal processing and machine learning that incorporate the advantages of both domains.

We present Imagen, a text-to-image diffusion model with an unprecedented degree of photorealism and a deep level of language understanding. Imagen builds on the power of large transformer language models in understanding text and hinges on the strength of diffusion models in high-fidelity image generation. Our key discovery is that generic large language models (e.g., T5), pretrained on text-only corpora, are surprisingly effective at encoding text for image synthesis: increasing the size of the language model in Imagen boosts both sample fidelity and image-text alignment much more than increasing the size of the image diffusion model. Imagen achieves a new state-of-the-art FID score of 7.27 on the COCO dataset, without ever training on COCO, and human raters find Imagen samples to be on par with the COCO data itself in image-text alignment. To assess text-to-image models in greater depth, we introduce DrawBench, a comprehensive and challenging benchmark for text-to-image models. With DrawBench, we compare Imagen with recent methods including VQ-GAN+CLIP, Latent Diffusion Models, and DALL-E 2, and find that human raters prefer Imagen over other models in side-by-side comparisons, both in terms of sample quality and image-text alignment.

We study image inverse problems with a normalizing flow prior. Our formulation views the solution as the maximum a posteriori estimate of the image conditioned on the measurements. This formulation allows us to use noise models with arbitrary dependencies as well as non-linear forward operators. We empirically validate the efficacy of our method on various inverse problems, including compressed sensing with quantized measurements and denoising with highly structured noise patterns. We also present initial theoretical recovery guarantees for solving inverse problems with a flow prior.

Given an inverse problem with a normalizing flow prior, we wish to estimate the distribution of the underlying signal conditioned on the observations. We approach this problem as a task of conditional inference on the pre-trained unconditional flow model. We first establish that this is computationally hard for a large class of flow models. Motivated by this, we propose a framework for approximate inference that estimates the target conditional as a composition of two flow models. This formulation leads to a stable variational inference training procedure that avoids adversarial training. Our method is evaluated on a variety of inverse problems and is shown to produce high-quality samples with uncertainty quantification. We further demonstrate that our approach can be amortized for zero-shot inference.

The recognition network in deep latent variable models such as variational autoencoders (VAEs) relies on amortized inference for efficient posterior approximation that can scale up to large datasets. However, this technique has also been demonstrated to select suboptimal variational parameters, often resulting in considerable additional error called the amortization gap. To close the amortization gap and improve the training of the generative model, recent works have introduced an additional refinement step that applies stochastic variational inference (SVI) to improve upon the variational parameters returned by the amortized inference model. In this paper, we propose the Buffered Stochastic Variational Inference (BSVI), a new refinement procedure that makes use of SVI’s sequence of intermediate variational proposal distributions and their corresponding importance weights to construct a new generalized importance-weighted lower bound. We demonstrate empirically that training the variational autoencoders with BSVI consistently out-performs SVI, yielding an improved training procedure for VAEs.