Neural networks (NNs) have been widely applied in tomographic imaging through data-driven training and image processing. One of the main challenges in using NNs in real medical imaging is the requirement of massive amounts of training data - which are not always available in clinical practice. In this article, we demonstrate that, on the contrary, one can directly execute image reconstruction using NNs without training data. The key idea is to bring in the recently introduced deep image prior (DIP) and merge it with electrical impedance tomography (EIT) reconstruction. DIP provides a novel approach to the regularization of EIT reconstruction problems by compelling the recovered image to be synthesized from a given NN architecture. Then, by relying on the NN's built-in back-propagation and the finite element solver, the conductivity distribution is optimized. Quantitative results based on simulation and experimental data show that the proposed method is an effective unsupervised approach capable of outperforming state-of-the-art alternatives.

Solving complex optimization problems in engineering and the physical sciences requires repetitive computation of multi-dimensional function derivatives, which commonly require computationally-demanding numerical differentiation such as perturbation techniques. In particular, Gauss-Newton methods are used for nonlinear inverse problems that require iterative updates to be computed from the Jacobian and allow for flexible incorporation of prior knowledge. Computationally more efficient alternatives are Quasi-Newton methods, where the repeated computation of the Jacobian is replaced by an approximate update, but unfortunately are often too restrictive for highly ill-posed problems. To overcome this limitation, we present a highly efficient data-driven Quasi-Newton method applicable to nonlinear inverse problems, by using the singular value decomposition and learning a mapping from model outputs to the singular values to compute the updated Jacobian. Enabling time-critical applications and allowing for flexible incorporation of prior knowledge necessary to solve ill-posed problems. We present results for the highly non-linear inverse problem of electrical impedance tomography with experimental data.

Shape-driven approaches have been proposed as an effective strategy for the electrical impedance tomography (EIT) reconstruction problem in recent years. In order to augment the shape-driven approaches, we propose a new method that transforms the shape to be reconstructed as basic primitives directly modeled by using Fourier representations. To allow automatic topological changes between the basic primitives and surrounding objects simultaneously, Boolean operations are employed. The Boolean operations with direct representation of primitives can be utilized for dimensionality and ill-posedness reduction, enabling feasible shape and topology optimization with shape-driven approaches. As a proof of principle, we leverage the proposed method for two dimensional shape reconstruction in EIT with various conductivity distributions. We demonstrate that our method is able to improve EIT reconstructions by enabling accurate shape and topology optimization.

A B-spline level set (BLS) based method is proposed for shape reconstruction in electrical impedance tomography (EIT). We assume that the conductivity distribution to be reconstructed is piecewise constant, transforming the image reconstruction problem into a shape reconstruction problem. The shape/interface of inclusions is implicitly represented by a level set function (LSF), which is modeled as a continuous parametric function expressed using B-spline functions. Starting from modeling the conductivity distribution with the B-spline based LSF, we show that the shape modeling allows us to compute the solution by restricting the minimization problem to the space spanned by the B-splines. As a consequence, the solution to the minimization problem is obtained in terms of the B-spline coefficients. We illustrate the behavior of this method using simulated as well as water tank data. In addition, robustness studies considering varying initial guesses, differing numbers of control points, and modeling errors caused by inhomogeneity are performed. Both simulation and experimental results show that the BLS-based approach offers clear improvements in preserving the sharp features of the inclusions in comparison to the recently published parametric level set method.

In this work, we propose a new shape reconstruction framework rooted in the concept of Boolean operations for electrical impedance tomography (EIT). Within the framework, the evolution of inclusion shapes and topologies are simultaneously estimated through an explicit boundary description. For this, we use B-spline curves as basic shape primitives for shape reconstruction and topology optimization. The effectiveness of the proposed approach is demonstrated using simulated and experimentally-obtained data (testing EIT lung imaging). In the study, improved preservation of sharp features is observed when employing the proposed approach relative to the recently developed moving morphable components-based approach. In addition, robustness studies of the proposed approach considering background inhomogeneity and differing numbers of B-spline curve control points are performed. It is found that the proposed approach is tolerant to modeling errors caused by background inhomogeneity and is also quite robust to the selection of control points.

This work proposes a novel shape-driven reconstruction approach for difference electrical impedance tomography (EIT). In the proposed approach, the reconstruction problem is formulated as a shape reconstruction problem and solved via an explicit and geometrical methodology, where the geometry of the embedded inclusions is represented by a shape and topology description function (STDF). To incorporate more geometry and prior information directly into the reconstruction and to provide better flexibility in the solution process, the concept of a moving morphable component (MMC) is applied here implying that MMC is treated as the basic building block of the embedded inclusions. Simulations, phantom studies, and in vivo pig data are used to test the proposed approach for the most popular biomedical application of EIT - lung imaging - and the performance is compared with the conventional linear approach. In addition, the modality's robustness is studied in cases where (i) modeling errors are caused by inhomogeneity in the background conductivity, and (ii) uncertainties in the contact impedances and reference state are present. The results of this work indicate that the proposed approach is tolerant to modeling errors and is fairly robust to typical EIT uncertainties, producing greatly improved image quality compared to the conventional linear approach.

This paper presents a B-spline-based shape reconstruction approach for electrical impedance tomography (EIT). In the proposed approach, the conductivity distribution to be reconstructed is assumed to be piecewise constant. The geometry of the inclusions is parameterized using B-spline curves, and the EIT forward solver is modified as a set of control points representing the inclusions' boundary to the data on the domain boundary. The low-order representation decreases the computational demand and reduces the ill-posedness of the EIT reconstruction problem. The performance of the proposed B-spline-based approach is tested with simulations that demonstrate the most popular biomedical application of EIT: lung imaging. The approach is experimentally validated using water tank data. In addition, robustness studies of the proposed approach considering varying initial guesses, inaccurately known contact impedances, differing numbers of control points, and degree of B-spline are performed. The simulation and experimental results show that the B-spline-based approach offers improvements in image quality in comparison to the traditional Fourier series-based reconstruction approach, as measured by quantitative metrics such as relative size coverage ratio and relative contrast. Inasmuch, the proposed approach is demonstrated to offer clear improvement in the ability to preserve the sharp properties of the inclusions to be imaged.

This paper presents a novel difference imaging approach based on the recently developed parametric level set (PLS) method for estimating the change in a target conductivity from electrical impedance tomography measurements. As in conventional difference imaging, the reconstruction of conductivity change is based on data sets measured from the surface of a body before and after the change. The key feature of the proposed approach is that the conductivity change to be reconstructed is assumed to be piecewise constant, while the geometry of the anomaly is represented by a shape-based PLS function employing Gaussian radial basis functions (GRBFs). The representation of the PLS function by using GRBF provides flexibility in describing a large class of shapes with fewer unknowns. This feature is advantageous, as it may significantly reduce the overall number of unknowns, improve the condition number of the inverse problem, and enhance the computational efficiency of the technique. To evaluate the proposed PLS-based difference imaging approach, results obtained via simulation, phantom study, and in vivo pig data are studied. We find that the proposed approach tolerates more modeling errors and leads to a significant improvement in image quality compared with the conventional linear approach.