Large language model (LLM) agents improve task performance by decomposing problems into role-specialized behaviors. However, their practical deployment is often limited by the computational cost and instability associated with the on-the-fly agent design for each user request. To address this, we present LLM Agents Factory, a retrieval-based framework that constructs domain-specific and Wikipedia-grounded agents on demand using a base of over 20K predetermined agent profiles. Our framework supports two modes: (1) agent profile retrieval via semantic search and (2) distillation into a compact model fine-tuned for direct agent generation. Experiments on MMLU, BIG-bench, and BIG-bench Hard in a single-agent scenario demonstrate that our retrieval-based agent construction surpasses non-agent baselines in accuracy while matching AutoGen generation quality with a 120B backbone at a substantially lower inference cost. Our work reveals that retrieval from a structured agent repository provides a cost-efficient, accurate, and controllable alternative to dynamic agent generation, responding to the strict demands of industrial applications. We provide the implementation code and the agent base in https://huggingface.co/frontier-ai/llm-agent-factory.

Alexandr Nesterov, Andrey Sakhovskiy, Ivan Sviridov, Airat Valiev, Vladimir Makharev, Petr Anokhin, Galina Zubkova, Elena Tutubalina. Proceedings of the 2025 Conference on Empirical Methods in Natural Language Processing. 2025.

In recent years, there has been substantial progress in using pretrained Language Models (LMs) on a range of tasks aimed at improving the understanding of biomedical texts. Nonetheless, existing biomedical LLMs show limited comprehension of complex, domain-specific concept structures and the factual information encoded in biomedical Knowledge Graphs (KGs). In this work, we propose BALI (Biomedical Knowledge Graph and Language Model Ali gnment), a novel joint LM and KG pre-training method that augments an LM with external knowledge by the simultaneous learning of a dedicated KG encoder and aligning the representations of both the LM and the graph. For a given textual sequence, we link biomedical concept mentions to the Unified Medical Language System (UMLS) KG and utilize local KG subgraphs as cross-modal positive samples for these mentions. Our empirical findings indicate that implementing our method on several leading biomedical LMs, such as PubMedBERT and BioLinkBERT, improves their performance on a range of language understanding tasks and the quality of entity representations, even with minimal pre-training on a small alignment dataset sourced from PubMed scientific abstracts.

We present a new manually annotated dataset of PubMed abstracts for concept normalization in Russian. It contains over 23,641 entity mentions in 756 documents linked to 4,544 unique concepts from the UMLS ontology. Compared to existing corpora, we explore two novel annotation characteristics: the nestedness of named entities and the incompleteness of the Russian medical terminology in UMLS. 4,424 entity mentions are linked to 1,535 unique English concepts absent in the Russian part of the UMLS ontology. We present several baselines for normalization over nested named entities obtained with state-of-the-art models such as SapBERT. Our experimental results show that models pre-trained on graph structural data from UMLS achieve superior performance in a zero-shot setting on bilingual terminology.

MOTIVATION: Drugs and diseases play a central role in many areas of biomedical research and healthcare. Aggregating knowledge about these entities across a broader range of domains and languages is critical for information extraction (IE) applications. To facilitate text mining methods for analysis and comparison of patient's health conditions and adverse drug reactions reported on the Internet with traditional sources such as drug labels, we present a new corpus of Russian language health reviews. RESULTS: The Russian Drug Reaction Corpus (RuDReC) is a new partially annotated corpus of consumer reviews in Russian about pharmaceutical products for the detection of health-related named entities and the effectiveness of pharmaceutical products. The corpus itself consists of two parts, the raw one and the labeled one. The raw part includes 1.4 million health-related user-generated texts collected from various Internet sources, including social media. The labeled part contains 500 consumer reviews about drug therapy with drug- and disease-related information. Labels for sentences include health-related issues or their absence. The sentences with one are additionally labeled at the expression level for identification of fine-grained subtypes such as drug classes and drug forms, drug indications and drug reactions. Further, we present a baseline model for named entity recognition (NER) and multilabel sentence classification tasks on this corpus. The macro F1 score of 74.85% in the NER task was achieved by our RuDR-BERT model. For the sentence classification task, our model achieves the macro F1 score of 68.82% gaining 7.47% over the score of BERT model trained on Russian data. AVAILABILITY AND IMPLEMENTATION: We make the RuDReC corpus and pretrained weights of domain-specific BERT models freely available at https://github.com/cimm-kzn/RuDReC. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

This article explores the problems of assigning documents to a limited number of topics and automating the process of topic structuring of Russian educational texts. For this purpose, we compiled an original corpus of school textbooks on Social Science. We utilized the Latent Dirichlet Allocation model for selection and comparative analysis of topics in the textbooks of different grades. This approach allows the reconstruction of the matrix of topics for each textbook in the orpus. The research demonstrated a grade ranked character of the topics in the text collection under study, in particular, there is a higher cohesion of topics in high school. The research also offers an innovative methodology of quantitative describing topics dynamics in the textbook collection. It allows visualization and comparison of strategies for presenting educational topics by different authors. The results received can be beneficial for both textbook writers as well as teachers and schoolchildren.