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Frederico Aleixo

dblp:319/5279 · DBLP profile ↗
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1ranked-venue papers
1as first author
1since 2021 · last 2023
—ORCID · none

Domains — the database's venue-derived domains; a paper can count in several

Artificial intelligence and machine learning · 1 · 1 first-author · 1 since 2021Theory of computation · 1 · 1 first-author · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Artificial intelligence
1 paper
Knowledge representation and reasoning · 100%
Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%
Theoretical computer science
1 paper
Mathematical optimization · 100%

Topics — the 3 heaviest of 3, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Knowledge, reasoning and agents › Knowledge representation and reasoning
model refinement
0.712023
Revising Boolean Logical Models of Biological Regulatory Networks · KR 2023
Bioinformatics and computational biology › gene regulation
regulatory network
0.712023
Revising Boolean Logical Models of Biological Regulatory Networks · KR 2023
Mathematical optimization
optimization
0.212023
Revising Boolean Logical Models of Biological Regulatory Networks · KR 2023
YearPublicationVenuePosition
2023 Revising Boolean Logical Models of Biological Regulatory Networks
abstract
Boolean regulatory networks are used to represent complex biological processes, modelling the interactions of biological compounds, such as proteins or genes, with each other and with other substances in a cell. Creating and maintaining computational models of these networks is crucial for comprehending corresponding cellular processes, as they allow reproducing known behaviours and testing new hypotheses and predictions in silico. In this context, model revision focuses on validating and (if necessary) repairing existing models based on new experimental data. However, model revision is commonly performed manually, which is inefficient and prone to error, and the few existing automated solutions either only apply to simpler networks or are limited in their revision process, since they may not be able to produce a solution within a reasonable time frame or miss the optimal solution. In this paper, we develop a solution for revising logical models of Boolean regulatory networks, able to find repairs that are consistent with provided, possibly incomplete experimental data, and minimal w.r.t. the differences to the original network. We show that our solution can be used to revise different real-world Boolean logical models very efficiently, surpassing a previous solution in terms of solved instances and with a considerable margin w.r.t. processing time.
Frederico Aleixo, Matthias Knorr 0001, João Leite 0001
KR1