Intradialytic hypotension (IDH) is a common complication among hemodialysis patients, adversely affecting quality of life and elevating mortality risk. IDH prediction enables physicians to take proactive measures, effectively reducing its occurrence. However, most prediction works rely on machine learning models, with a focus on real-time or session-level IDH. Hemodialysis patient data is multi-type and temporal, necessitating research on patient condition representation and temporal information utilization. Knowledge graphs (KGs) offer flexible data modeling and encompass rich structured information. This study represents patients using KGs and reason on graph structures to predict IDH. To study monthly IDH and utilize temporal information, a temporal patient KG is constructed. Patient KGs are first built at the monthly granularity based on data of 532 patients between January 2017 and August 2022. Six sequential monthly KGs are then combined into an observation window, resulting in a temporal KG dataset of 15,807 independent windows from 458 patients. The aim of this study is to utilize information from multiple months within a window to predict frequent IDH in the last month. However, the characteristics of IDH scenario and generalizability requirement pose challenges for the application of general KG reasoning models. Therefore, we adopt neighborhood-based KG reasoning and devise a visible feature guided patient-centric graph convolution to obtain patients' generalizable representations. Finally, patient representations in a window are fused using a sequential model, and processed by a prediction MLP to obtain the prediction results. Compared to 7 classic machine learning models, our model demonstrates superior performance in comprehensive metrics such as accuracy and F1 score.

In the field of representation learning on knowledge graphs (KGs), a hyper-relational fact consists of a main triple and several auxiliary attribute-value descriptions, which is considered more comprehensive and specific than a triple-based fact. However, currently available hyper-relational KG embedding methods in a single view are limited in application because they weaken the hierarchical structure that represents the affiliation between entities. To overcome this limitation, we propose a dual-view hyper-relational KG structure (DH-KG) that contains a hyper-relational instance view for entities and a hyper-relational ontology view for concepts that are abstracted hierarchically from the entities. This paper defines link prediction and entity typing tasks on DH-KG for the first time and constructs two DH-KG datasets, JW44K-6K, extracted from Wikidata, and HTDM based on medical data. Furthermore, we propose DHGE, a DH-KG embedding model based on GRAN encoders, HGNNs, and joint learning. DHGE outperforms baseline models on DH-KG, according to experimental results. Finally, we provide an example of how this technology can be used to treat hypertension. Our model and new datasets are publicly available.

Complex query answering (CQA) is an essential task for multi-hop and logical reasoning on knowledge graphs (KGs). Currently, most approaches are limited to queries among binary relational facts and pay less attention to n-ary facts (n≥2) containing more than two entities, which are more prevalent in the real world. Moreover, previous CQA methods can only make predictions for a few given types of queries and cannot be flexibly extended to more complex logical queries, which significantly limits their applications. To overcome these challenges, in this work, we propose a novel N-ary Query Embedding (NQE) model for CQA over hyper-relational knowledge graphs (HKGs), which include massive n-ary facts. The NQE utilizes a dual-heterogeneous Transformer encoder and fuzzy logic theory to satisfy all n-ary FOL queries, including existential quantifiers (∃), conjunction (∧), disjunction (∨), and negation (¬). We also propose a parallel processing algorithm that can train or predict arbitrary n-ary FOL queries in a single batch, regardless of the kind of each query, with good flexibility and extensibility. In addition, we generate a new CQA dataset WD50K-NFOL, including diverse n-ary FOL queries over WD50K. Experimental results on WD50K-NFOL and other standard CQA datasets show that NQE is the state-of-the-art CQA method over HKGs with good generalization capability. Our code and dataset are publicly available.

Multi-hop logical reasoning over knowledge graph plays a fundamental role in many artificial intelligence tasks. Recent complex query embedding methods for reasoning focus on static KGs, while temporal knowledge graphs have not been fully explored. Reasoning over TKGs has two challenges: 1. The query should answer entities or timestamps; 2. The operators should consider both set logic on entity set and temporal logic on timestamp set. To bridge this gap, we introduce the multi-hop logical reasoning problem on TKGs and then propose the first temporal complex query embedding named Temporal Feature-Logic Embedding framework (TFLEX) to answer the temporal complex queries. Specifically, we utilize fuzzy logic to compute the logic part of the Temporal Feature-Logic embedding, thus naturally modeling all first-order logic operations on the entity set. In addition, we further extend fuzzy logic on timestamp set to cope with three extra temporal operators (**After**, **Before** and **Between**). Experiments on numerous query patterns demonstrate the effectiveness of our method.