Medical Vision-language models (VLMs) have shown remarkable performances in various medical imaging domains such as histopathology by leveraging pre-trained, contrastive models that exploit visual and textual information. However, histopathology images may exhibit severe domain shifts, such as staining, contamination, blurring, and noise, which may severely degrade the VLM’s downstream performance. In this work, we introduce Histopath-C, a new benchmark with realistic synthetic corruptions designed to mimic real-world distribution shifts observed in digital histopathology. Our framework dynamically applies corruptions to any available dataset and evaluates Test-Time Adaptation (TTA) mechanisms on the fly. We then propose LATTE, a transductive, low-rank adaptation strategy that exploits multiple text templates, mitigating the sensitivity of histopathology VLMs to diverse text inputs. Our approach outperforms state-of-the-art TTA methods originally designed for natural images across a breadth of histopathology datasets, demonstrating the effectiveness of our proposed design for robust adaptation in histopathology images. Code and data are available at https://github.com/Mehrdad-Noori/Histopath-C.

Transductive few-shot learning has recently triggered wide attention in computer vision. Yet, current methods introduce key hyper-parameters, which control the prediction statistics of the test batches, such as the level of class balance, affecting performances significantly. Such hyper-parameters are empirically grid-searched over validation data, and their configurations may vary substantially with the target dataset and pre-training model, making such empirical searches both sub-optimal and computationally intractable. In this work, we advocate and introduce the unrolling paradigm, also referred to as "learning to optimize", in the context of few-shot learning, thereby learning efficiently and effectively a set of optimized hyperparameters. Specifically, we unroll a generalization of the ubiquitous Expectation-Maximization (EM) optimizer into a neural network architecture, mapping each of its iterates to a layer and learning a set of key hyper-parameters over validation data. Our unrolling approach covers various statistical feature distributions and pre-training paradigms, including recent foundational vision-language models and standard vision-only classifiers. We report comprehensive experiments, which cover a breadth of fine-grained downstream image classification tasks, showing significant gains brought by the proposed unrolled EM algorithm over iterative variants. The achieved improvements reach up to 10% and 7.5% on vision-only and vision-language benchmarks, respectively. The source code and learned parameters are available at https://github.com/ZhouLong0/UNEM-Transductive.

In a recent, strongly emergent literature on few-shot CLIP adaptation, Linear Probe (LP) has been often reported as a weak baseline. This has motivated intensive research building convoluted prompt learning or feature adaptation strategies. In this work, we propose and exam-ine from convex-optimization perspectives a generalization of the standard LP baseline, in which the linear classifier weights are learnable functions of the text embedding, with class-wise multipliers blending image and text knowledge. As our objective function depends on two types of variables, i.e., the class visual prototypes and the learnable blending parameters, we propose a computationally efficient block coordinate Majorize-Minimize (MM) descent algorithm. In our full-batch MM optimizer, which we coin LP++, step sizes are implicit, unlike standard gradient descent practices where learning rates are intensively searched over validation sets. By examining the mathematical properties of our loss (e.g., Lipschitz gradient continuity), we build ma-jorizing functions yielding data-driven learning rates and derive approximations of the loss's minima, which provide data-informed initialization of the variables. Our image-language objective function, along with these non-trivial optimization insights and ingredients, yields, surprisingly, highly competitive few-shot CLIP performances. Furthermore, LP++ operates in black-box, relaxes intensive validation searches for the optimization hyper-parameters, and runs orders-of-magnitudes faster than state-of-the-art few-shot CLIP adaptation methods. Our code is available at: https://github.com/FereshteShakeri/FewShot-CLIP-Strong-Baseline.git.

Transductive inference has been widely investigated in few-shot image classification, but completely overlooked in the recent, fast growing literature on adapting vision-langage models like CLIP. This paper addresses the transductive zero-shot and few-shot CLIP classification challenge, in which inference is performed jointly across a mini-batch of unlabeled query samples, rather than treating each instance independently. We initially construct informative vision-text probability features, leading to a classification problem on the unit simplex set. Inspired by Expectation-Maximization (EM), our optimization-based classification objective models the data probability distribution for each class using a Dirichlet law. The minimization problem is then tackled with a novel block Majorization-Minimization algorithm, which simultaneously estimates the distribution parameters and class assignments. Extensive numerical experiments on 11 datasets underscore the benefits and efficacy of our batch inference approach. On zero-shot tasks with test batches of 75 samples, our approach yields near 20% improvement in ImageNet accuracy over CLIP's zero-shot performance. Additionally, we outperform state-of-the-art methods in the few-shot setting. The code is available at: https://github.com/SegoleneMartin/transductive-CLIP.