Qihua Dong, Yitian Zhang, Huimin Zeng, Yizhou Wang, Jianglin Lu, Kuo Yang, Yun Fu. Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2026.

Accurate medical image segmentation is critical to effective treatment strategies. Existing transformer-based methods for image segmentation mostly split the input image into a fixed and regular grid and regard cells in the grid as the vision tokens. However, not all tokens are of equal importance in the medical segmentation tasks, e.g., the tokens in tumor areas must be processed in a higher resolution than the background tokens which can be easily predicted with fewer transformer layers. In this paper, we propose a simple yet efficient segmentation framework called Top-Down Transformer (TDFormer), which incorporates a spatially adaptive token generation scheme into the transformer. The proposed top-down token generation comprises the following three components: attentiveness calculation, token splitting, and token fusion, where the collaboration of these components gradually fuses redundant background tokens and focuses only on the most critical areas. This allows for allocating more computation to process tokens containing delicate details in a finer resolution. Extensive experiments are conducted to demonstrate the robustness and effectiveness of the proposed TDFormer, that our method are superior to other state-of-the-art methods on the following publicly accessible datasets: BTCV Challenge, LiTS and BraTS 2020. We also dissect our method and evaluate the performance of each component.

Existing camouflaged object detection (COD) methods rely heavily on large-scale datasets with pixel-wise annotations. However, due to the ambiguous boundary, annotating camouflage objects pixel-wisely is very time-consuming and labor-intensive, taking ~60mins to label one image. In this paper, we propose the first weakly-supervised COD method, using scribble annotations as supervision. To achieve this, we first relabel 4,040 images in existing camouflaged object datasets with scribbles, which takes ~10s to label one image. As scribble annotations only describe the primary structure of objects without details, for the network to learn to localize the boundaries of camouflaged objects, we propose a novel consistency loss composed of two parts: a cross-view loss to attain reliable consistency over different images, and an inside-view loss to maintain consistency inside a single prediction map. Besides, we observe that humans use semantic information to segment regions near the boundaries of camouflaged objects. Hence, we further propose a feature-guided loss, which includes visual features directly extracted from images and semantically significant features captured by the model. Finally, we propose a novel network for COD via scribble learning on structural information and semantic relations. Our network has two novel modules: the local-context contrasted (LCC) module, which mimics visual inhibition to enhance image contrast/sharpness and expand the scribbles into potential camouflaged regions, and the logical semantic relation (LSR) module, which analyzes the semantic relation to determine the regions representing the camouflaged object. Experimental results show that our model outperforms relevant SOTA methods on three COD benchmarks with an average improvement of 11.0% on MAE, 3.2% on S-measure, 2.5% on E-measure, and 4.4% on weighted F-measure.

Medical image registration is a critical task that estimates the spatial correspondence between pairs of images. However, current traditional and deep-learning-based methods rely on similarity measures to generate a deforming field, which often results in disproportionate volume changes in dissimilar regions, especially in tumor regions. These changes can significantly alter the tumor size and underlying anatomy, which limits the practical use of image registration in clinical diagnosis. To address this issue, we have formulated image registration with tumors as a constraint problem that preserves tumor volumes while maximizing image similarity in other normal regions. Our proposed strategy involves a two-stage process. In the first stage, we use similarity-based registration to identify potential tumor regions by their volume change, generating a soft tumor mask accordingly. In the second stage, we propose a volume-preserving registration with a novel adaptive volume-preserving loss that penalizes the change in size adaptively based on the masks calculated from the previous stage. Our approach balances image similarity and volume preservation in different regions, i.e., normal and tumor regions, by using soft tumor masks to adjust the imposition of volume-preserving loss on each one. This ensures that the tumor volume is preserved during the registration process. We have evaluated our strategy on various datasets and network architectures, demonstrating that our method successfully preserves the tumor volume while achieving comparable registration results with state-of-the-art methods. Our codes is available at: https://dddraxxx.github.io/Volume-Preserving-Registration/.

Medical image segmentation is almost the most important pre-processing procedure in computer-aided diagnosis but is also a very challenging task due to the complex shapes of segments and various artifacts caused by medical imaging, (i.e., low-contrast tissues, and non-homogenous textures). In this paper, we propose a simple yet effective segmentation framework that incorporates the geometric prior and contrastive similarity into the weakly-supervised segmentation framework in a loss-based fashion. The proposed geometric prior built on point cloud provides meticulous geometry to the weakly-supervised segmentation proposal, which serves as better supervision than the inherent property of the bounding-box annotation (i.e., height and width). Furthermore, we propose the contrastive similarity to encourage organ pixels to gather around in the contrastive embedding space, which helps better distinguish low-contrast tissues. The proposed contrastive embedding space can make up for the poor representation of the conventionally-used gray space. Extensive experiments are conducted to verify the effectiveness and the robustness of the proposed weakly-supervised segmentation framework. The proposed framework are superior to state-of-the-art weakly-supervised methods on the following publicly accessible datasets: LiTS 2017 Challenge, KiTS 2021 Challenge and LPBA40. We also dissect our method and evaluate the performance of each component.