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Sharon Bruckner

dblp:33/1036 · DBLP profile ↗
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5ranked-venue papers
5as first author
0since 2021 · last 2014
—ORCID · none

Domains — the database's venue-derived domains; a paper can count in several

Theory of computation · 2 · 2 first-authorApplied, interdisciplinary, general and emerging computing · 2 · 2 first-authorGraphics, computer vision, multimedia, augmented reality and games · 1 · 1 first-author

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 4, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › network bioinformatics › biological network analysis › subnetwork detection
network querying
0.112009
Topology-Free Querying of Protein Interaction Networks · RECOMB 2009
Bioinformatics and computational biology › protein analysis › protein-protein interaction
protein-protein interaction network analysis
0.112009
Topology-Free Querying of Protein Interaction Networks · RECOMB 2009

Methods — techniques the papers use, named apart from their topics

integer linear programming · 0.1dynamic programming · 0.1
YearPublicationVenuePosition
2014 A Graph Modification Approach for Finding Core-Periphery Structures in Protein Interaction Networks
Sharon Bruckner, Falk Hüffner, Christian Komusiewicz
WABI1
2013 Evaluation of ILP-Based Approaches for Partitioning into Colorful Components
Sharon Bruckner, Falk Hüffner, Christian Komusiewicz, Rolf Niedermeier
SEA1
2013 Finding Modules in Networks with Non-modular Regions
Sharon Bruckner, Bastian Kayser, Tim Conrad 0001
SEA1
2012 Partitioning into Colorful Components by Minimum Edge Deletions
Sharon Bruckner, Falk Hüffner, Christian Komusiewicz, Rolf Niedermeier, Sven Thiel, Johannes Uhlmann
CPM1
2009 Topology-Free Querying of Protein Interaction Networks
abstract
In the network querying problem, one is given a protein complex or pathway of species A and a protein-protein interaction network of species B; the goal is to identify subnetworks of B that are similar to the query in terms of sequence, topology, or both. Existing approaches mostly depend on knowledge of the interaction topology of the query in the network of species A; however, in practice, this topology is often not known. To address this problem, we develop a topology-free querying algorithm, which we call Torque. Given a query, represented as a set of proteins, Torque seeks a matching set of proteins that are sequence-similar to the query proteins and span a connected region of the network, while allowing both insertions and deletions. The algorithm uses alternatively dynamic programming and integer linear programming for the search task. We test Torque with queries from yeast, fly, and human, where we compare it to the QNet topology-based approach, and with queries from less studied species, where only topology-free algorithms apply. Torque detects many more matches than QNet, while giving results that are highly functionally coherent.
Sharon Bruckner, Falk Hüffner, Richard M. Karp, Ron Shamir, Roded Sharan
RECOMB1