Latent fingerprints are among the most important and widely used evidence in crime scenes, digital forensics and law enforcement worldwide. Despite the number of advancements reported in recent works, we note that significant open issues such as independent benchmarking and lack of large-scale evaluation databases for improving the algorithms are inadequately addressed. The available databases are mostly of semi-public nature, lack of acquisition in the wild environment, and post-processing pipelines. Moreover, they do not represent a realistic capture scenario similar to real crime scenes, to benchmark the robustness of the algorithms. Further, existing databases for latent fingerprint recognition do not have a large number of unique subjects/fingerprint instances or do not provide ground truth/reference fingerprint images to conduct a cross-comparison against the latent. In this paper, we introduce a new wild large-scale latent fingerprint database that includes five different acquisition scenarios: reference fingerprints from (1) optical and (2) capacitive sensors, (3) smartphone fingerprints, latent fingerprints captured from (4) wall surface, (5) Ipad surface, and (6) aluminium foil surface. The new database consists of 1,318 unique fingerprint instances captured in all above mentioned settings. A total of 2,636 reference fingerprints from optical and capacitive sensors, 1,318 fingerphotos from smartphones, and 9,224 latent fingerprints from each of the 132 subjects were provided in this work. The dataset is constructed considering various age groups, equal representations of genders and backgrounds. In addition, we provide an extensive set of analysis of various subset evaluations to highlight open challenges for future directions in latent fingerprint recognition research.

As one of the most vital methods in drug development, drug repositioning emphasizes further analysis and research of approved drugs based on the existing large amount of clinical and experimental data to identify new indications of drugs. However, the existing drug repositioning methods didn't achieve enough prediction performance, and these methods do not consider the effectiveness information of drugs, which make it difficult to obtain reliable and valuable results. In this study, we proposed a drug repositioning framework termed DRONet, which make full use of effectiveness comparative relationships (ECR) among drugs as prior information by combining network embedding and ranking learning. We utilized network embedding methods to learn the deep features of drugs from a heterogeneous drug-disease network, and constructed a high-quality drug-indication data set including effectiveness-based drug contrast relationships. The embedding features and ECR of drugs are combined effectively through a designed ranking learning model to prioritize candidate drugs. Comprehensive experiments show that DRONet has higher prediction accuracy (improving 87.4% on Hit@1 and 37.9% on mean reciprocal rank) than state of the art. The case analysis also demonstrates high reliability of predicted results, which has potential to guide clinical drug development.

Surviva1 analysis is a widely used statistical approach to model and analysis time-to-event data, which consists of event occurrence and duration before it occurs. Traditional statistical methods have good interpretability but performance is limited by strong assumptions. In recent years, methods based on machine learning, especially deep learning, have achieved success, but the lack of interpretability limits their real-world applications. This paper proposes a novel interpretable deep learning survival analysis method, RESurv, which predicts the hazard directly without any priori assumptions. Experiments on multiple public datasets validate that RESurv outperforms or approaches state-of-the-art methods. We further estimate the inflence of exposure factors on prognosis at individual level by using counterfactual approaches. Patients are then divided into subgroups by hierarchical clustering. Significant differences in risk response patterns and prognosis suggest heterogeneity in their pathological mechanisms. We explore the risk factors between subpopulations identified by different characteristics and find distinct risk patterns among them, some of which are consistent with medical research findings. The results suggest the potential of RESurv to estimate individual risk, and thereby revealing the heterogeneity of risk response patterns across the populations.