SUMMARY: The rapid growth of DNA sequencing throughput in recent years implies that graphical interfaces for viewing and correcting errors must now handle large numbers of reads, efficiently pinpoint regions of interest and automate as many tasks as possible. We have adapted consed to reflect this. To allow full-feature editing of large datasets while keeping memory requirements low, we developed a viewer, bamScape, that reads billion-read BAM files, identifies and displays problem areas for user review and launches the consed graphical editor on user-selected regions, allowing, in addition to longstanding consed capabilities such as assembly editing, a variety of new features including direct editing of the reference sequence, variant and error detection, display of annotation tracks and the ability to simultaneously process a group of reads. Many batch processing capabilities have been added. AVAILABILITY: The consed package is free to academic, government and non-profit users, and licensed to others for a fee by the University of Washington. The current version (26.0) is available for linux, macosx and solaris systems or as C++ source code. It includes a user's manual (with exercises) and example datasets. http://www.phrap.org/consed/consed.html CONTACT: [email protected] .

Large-scale commodity clusters are used in an increasing number of domains: academic, research, and industrial environments. At the same time, these clusters are exposed to an increasing number of attacks coming from public networks. Therefore, mechanisms for efficiently and flexibly managing security have now become an essential requirement for clusters. However, despite the growing importance of cluster security, this field has been only minimally addressed by contemporary cluster administration techniques. This paper presents a high-level view of existing security challenges related to clusters and proposes a structured approach for handling security in clustered servers. The goal of this paper is to identify various necessarily-distributed security services and their related characteristics as a means of enhancing cluster security.