A need has arisen to manipulate a small biological object, such as an embryo, cell, and microbe. Bio-micromanipulation is important for biology and the bioengineering field. However, it is very difficult, since the object is very small, kept in liquid, and observed by an optical microscope. The image of the microscope is two dimensional, so it is hard to manipulate the target in 3D space. The object is fragile, so it is hard to manipulate safely. To improve the manipulation works, the authors propose the viewpoint selection method in VR space, and a bilateral control system to improve manipulation of the micro object under the microscope.

It is important to manipulate a biological small object, such as a cell and embryo. Three-dimensional high speed micromanipulation is needed as a fundamental technology for biology and bio-engineering application. In this paper, we focus on the contact type micromanipulation in the liquid. We designed and made a contact type micromanipulation system which has a 3-DOF narrow range positioning system on a 3-DOF wide range positioning system. We developed a micro tri-axial force sensor which can be installed near the tip of the end effector. Performance of this micro-force sensor is presented.