Demonstration venue · read-only. Every page can be browsed; the buttons that would change it are switched off. Create an account to run TaxoReview on your own data. A simulation from public publication records: the people listed were not invited and did not agree to review.
? Tutorial for this page

Edith Lee

dblp:383/8631 · DBLP profile ↗
← Back
1ranked-venue papers
0as first author
1since 2021 · last 2025
0000-0001-7419-4707ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 1 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › protein sequence analysis
antibody sequence analysis
0.912025
deepNGS navigator: exploring antibody NGS datasets using deep contrastive learning · Bioinform. 2025

Methods — techniques the papers use, named apart from their topics

language model · 0.9contrastive learning · 0.9
YearPublicationVenuePosition
2025 deepNGS navigator: exploring antibody NGS datasets using deep contrastive learning
abstract
MOTIVATION: High-throughput sequencing uncovers how B-cells adapt in response to antigens by generating B-cell-receptor (BCR) sequences at an unprecedented scale. As BCR datasets grow to millions of sequences, using efficient computational methods becomes crucial. One important aspect of antibody sequence analysis is detecting clonal families or clusters of related sequences, whether they come from immunization, synthetic-libraries or even ML-generated datasets. RESULTS: We introduce deepNGS Navigator, a computational tool that leverages language models and contrastive learning to transform antibody sequences into intuitive 2D representations. The resulting 2D maps offer a visualization of overall diversity of input datasets, which can be clustered based on the sequence distances and their densities across the map. Beyond grouping related sequences, the 2D maps also represent mutational patterns inferred from sequence embeddings, enabling trajectory analysis and clustering within the projected space. By overlaying properties such as charge, the map helps identify clusters of interest for further investigation while also flagging potentially noisy or non-specific sequences with higher risk. We demonstrate deepNGS Navigator's utilities on several datasets, including: (i) a synthetic-library from a yeast-display targeting HER2, (ii) a machine learning-generated dataset with a hierarchical structure, (iii) NGS sequences from a llama immunized against COVID RBD, (iv) human naive and memory B-cell sequences, and (v) an in silico dataset simulating B-cell clonal lineages. AVAILABILITY AND IMPLEMENTATION: The deepNGS Navigator source code is available at: github.com/prescient-design/deepngs-navigator and github.com/prescient-design/deepngs-navigator-panel-app.
Homa Mohammadi Peyhani, Edith Lee, Richard Bonneau, Vladimir Gligorijevic, Jae Hyeon Lee
Bioinform.2