Equal access to digital technologies is critical for education, employment, and social participation. However, mainstream interfaces are visually oriented, creating steep learning curves and frequent obstacles for screen reader users, and limiting their independence and opportunities. Existing support is inadequate—tutorials mainly target sighted users, while human assistance lacks real-time availability. We introduce AskEase, an on-demand AI assistant that provides step-by-step, screen reader user-friendly guidance for computer use. AskEase manages multiple sources of context to infer user intent and deliver precise, situation-specific guidance. Its seamless interaction design minimizes disruption and reduces the effort of seeking help. We demonstrated its effectiveness through representative usage scenarios and robustness tests. In a within-subjects study with 12 screen reader users, AskEase significantly improved task success while reducing perceived workload, including physical demand, effort, and frustration. These results demonstrate the potential of LLM-powered assistants to promote accessible computing and expand opportunities for users with visual impairments.

Generative AI agents are reshaping human-computer interaction, shifting users from direct task execution to supervising machine-driven actions, especially the rise of “vibe coding” in programming. Yet little is known about how programmers who use screen readers interact with AI code assistants in practice. We conducted a longitudinal study with 16 blind and low-vision programmers. Participants completed a GitHub Copilot tutorial, engaged with a programming task, and provided initial feedback. After two weeks of AI-assisted programming, follow-ups examined how their practices and perceptions evolved. Our findings show that code assistants enhanced programming efficiency and bridged accessibility gaps. However, participants struggled to convey intent, interpret AI outputs, and manage multiple views while maintaining situational awareness. They showed diverse preferences for accessibility features, expressed a need to balance automation with control, and encountered barriers when learning to use these tools. Furthermore, we propose design principles and recommendations for more accessible and inclusive human-AI collaborations.