Neurological studies are often concerned with identifying abnormalities in brain structure affecting asymmetry between left and right hemispheres. This paper presents techniques which allow measurement and characterisation of differences between neuroanatomic structures due to variation in both shape and receptor distribution. This provides a potentially powerful tool for identifying subtle pathological asymmetries. We propose a combination of appearance modelling and linear discriminant analysis and present preliminary results of the technique applied to 2D hippocampal autoradiographs. We also describe experiments testing the relative performance of variants of our method to test assumptions about the nature of the analysis and the nature of the data.

This paper outlines a set of proposals for the development of system documentation based on an analysis of user needs. It is suggested that existing documentation is not sensitive enough to the variety of levels of user expertise, nor to the variety of contexts in which on-line help is required. We outline three specific proposals for fulfilling these needs: a quick reference facility, a command-line database, and a facility for full explanation and instruction, and suggest a number of ways in which users might access these facilities. Finally, we suggest a way of combining these facilities into an integrated structured manual, offering more effective user support than is currently provided.