Motion sickness (MS) is a common experience of travelers. To provide insights into brain dynamics associated with MS, this study recruited 19 subjects to participate in an electroencephalogram (EEG) experiment in a virtual-reality driving environment. When riding on consecutive winding roads, subjects experienced postural instability and sensory conflict between visual and vestibular stimuli. Meanwhile, subjects rated their level of MS on a six-point scale. Independent component analysis (ICA) was used to separate the filtered EEG signals into maximally temporally independent components (ICs). Then, reduced logarithmic spectra of ICs of interest, using principal component analysis, were decomposed by ICA again to find spectrally fixed and temporally independent modulators (IMs). Results demonstrated that a higher degree of MS accompanied increased activation of alpha (r = 0.421) and gamma (r =0.478) IMs across remote-independent brain processes, covering motor, parietal and occipital areas. This co-modulatory spectral change in alpha and gamma bands revealed the neurophysiological demand to regulate conflicts among multi-modal sensory systems during MS.

Past studies reported that the main electrogastrography (EEG) dynamic changes related to motion sickness (MS) were occurred in occipital, parietal, and somatosensory brain area, especially in the power increasing of the alpha band (8-13 Hz) and theta band (4-7 Hz) which had positive correlation with the subjective MS level. Depend on these main findings correlated with MS, we attempt to develop an EEG based classification system to automatically classify subject's MS level and find the suitable EEG features via common feature extraction, selection and classifiers technologies in this study. If we can find the regulations and then develop an algorithm to predict MS occurring, it would be a great benefit to construct a safe and comfortable environment for all drivers and passengers when they are cruising in the car, bus, ship or airplane. EEG is one of the best methods for monitoring the brain dynamics induced by motion-sickness because of its high temporal resolution and portability. After collecting the EEG signals and subjective MS level in a realistic driving environment, we first do the data pre-processing part including ICA, component clustering analysis and time-frequency analysis. Then we adopt three common feature extractions and two feature selections (FE/FS) technologies to extract or select the correlated features such as principal component analysis (PCA), linear discriminate analysis (LDA), nonparametric weighted feature extraction (NWFE), forward feature selections (FFS) and backward feature selections (BFS) and feed the feature maps into three classifiers (Gaussian Maximum Likelihood Classifier (ML), k-Nearest-Neighbor Classifier (kNN) and Support Vector Machine (SVM)). Experimental results show that classification performance of all our proposed technologies can be reached almost over 95%. It means it is possible to apply the effective technology combination to predict the subject's MS level in the real life applications. The better combination in this study is using LDA and Gaussian based ML classifier. This advantage can be widely used in machine learning area for developing the prediction algorithms in the future.