Routine ultrasound exam in the second and third trimesters of pregnancy involves manually measuring fetal head and brain structures in 2-D scans. The procedure requires a sonographer to find the standardized visualization planes with a probe and manually place measurement calipers on the structures of interest. The process is tedious, time consuming, and introduces user variability into the measurements. This paper proposes an automatic fetal head and brain (AFHB) system for automatically measuring anatomical structures from 3-D ultrasound volumes. The system searches the 3-D volume in a hierarchy of resolutions and by focusing on regions that are likely to be the measured anatomy. The output is a standardized visualization of the plane with correct orientation and centering as well as the biometric measurement of the anatomy. The system is based on a novel framework for detecting multiple structures in 3-D volumes. Since a joint model is difficult to obtain in most practical situations, the structures are detected in a sequence, one-by-one. The detection relies on Sequential Estimation techniques, frequently applied to visual tracking. The interdependence of structure poses and strong prior information embedded in our domain yields faster and more accurate results than detecting the objects individually. The posterior distribution of the structure pose is approximated at each step by sequential Monte Carlo. The samples are propagated within the sequence across multiple structures and hierarchical levels. The probabilistic model helps solve many challenges present in the ultrasound images of the fetus such as speckle noise, signal drop-out, shadows caused by bones, and appearance variations caused by the differences in the fetus gestational age. This is possible by discriminative learning on an extensive database of scans comprising more than two thousand volumes and more than thirteen thousand annotations. The average difference between ground truth and automatic measurements is below 2 mm with a running time of 6.9 s (GPU) or 14.7 s (CPU). The accuracy of the AFHB system is within inter-user variability and the running time is fast, which meets the requirements for clinical use.

3D ultrasound imaging has been increasingly used in clinics for fetal examination. However, manually searching for the optimal view of the fetal face in 3D ultrasound volumes is cumbersome and time-consuming even for expert physicians and sonographers. In this paper we propose a learning-based approach which combines both 3D and 2D information for automatic and fast fetal face detection from 3D ultrasound volumes. Our approach applies a new technique - constrained marginal space learning - for 3D face mesh detection, and combines a boosting-based 2D profile detection to refine 3D face pose. To enhance the rendering of the fetal face, an automatic carving algorithm is proposed to remove all obstructions in front of the face based on the detected face mesh. Experiments are performed on a challenging 3D ultrasound data set containing 1010 fetal volumes. The results show that our system not only achieves excellent detection accuracy but also runs very fast - it can detect the fetal face from the 3D data in 1 second on a dual-core 2.0 GHz computer.

In this paper, we present a novel probabilistic framework for automatic follicle quantification in 3D ultrasound data. The proposed framework robustly estimates size and location of each individual ovarian follicle by fusing the information from both global and local context. Follicle candidates at detected locations are then segmented by a novel database guided segmentation method. To efficiently search hypothesis in a high dimensional space for multiple object detection, a clustered marginal space learning approach is introduced. Extensive evaluations conducted on 501 volumes containing 8108 follicles showed that our method is able to detect and segment ovarian follicles with high robustness and accuracy. It is also much faster than the current ultrasound manual workflow. The proposed method is able to streamline the clinical workflow and improve the accuracy of existing follicular measurements.

The use of 3-D ultrasound data has several advantages over 2-D ultrasound for fetal biometric measurements, such as considerable decrease in the examination time, possibility of post-exam data processing by experts and the ability to produce 2-D views of the fetal anatomies in orientations that cannot be seen in common 2-D ultrasound exams. However, the search for standardized planes and the precise localization of fetal anatomies in ultrasound volumes are hard and time consuming processes even for expert physicians and sonographers. The relative low resolution in ultrasound volumes, small size of fetus anatomies and inter-volume position, orientation and size variability make this localization problem even more challenging. In order to make the plane search and fetal anatomy localization problems completely automatic, we introduce a novel principled probabilistic model that combines discriminative and generative classifiers with contextual information and sequential sampling. We implement a system based on this model, where the user queries consist of semantic keywords that represent anatomical structures of interest. After queried, the system automatically displays standardized planes and produces biometric measurements of the fetal anatomies. Experimental results on a held-out test set show that the automatic measurements are within the inter-user variability of expert users. It resolves for position, orientation and size of three different anatomies in less than 10 seconds in a dual-core computer running at 1.7 GHz.

We propose a novel method for the automatic detection and measurement of fetal anatomical structures in ultrasound images. This problem offers a myriad of challenges, including: difficulty of modeling the appearance variations of the visual object of interest, robustness to speckle noise and signal dropout, and large search space of the detection procedure. Previous solutions typically rely on the explicit encoding of prior knowledge and formulation of the problem as a perceptual grouping task solved through clustering or variational approaches. These methods are constrained by the validity of the underlying assumptions and usually are not enough to capture the complex appearances of fetal anatomies. We propose a novel system for fast automatic detection and measurement of fetal anatomies that directly exploits a large database of expert annotated fetal anatomical structures in ultrasound images. Our method learns automatically to distinguish between the appearance of the object of interest and background by training a constrained probabilistic boosting tree classifier. This system is able to produce the automatic segmentation of several fetal anatomies using the same basic detection algorithm. We show results on fully automatic measurement of biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), femur length (FL), humerus length (HL), and crown rump length (CRL). Notice that our approach is the first in the literature to deal with the HL and CRL measurements. Extensive experiments (with clinical validation) show that our system is, on average, close to the accuracy of experts in terms of segmentation and obstetric measurements. Finally, this system runs under half second on a standard dual-core PC computer.