It has become increasingly common that sponsored content (i.e., paid ads) and non-sponsored content are jointly displayed to users, especially on e-commerce platforms. Thus, both of these contents may interact together to influence their engagement behaviors. In general, sponsored content helps brands achieve their marketing goals and provides ad revenue to the platforms. In contrast, non-sponsored content contributes to the long-term health of the platform through increasing users' engagement. A key conundrum to platforms is learning how to blend both of these contents allowing their interactions to be considered and balancing these business objectives. This paper proposes a system built for this purpose and applied to product detail pages of JD.COM, an e-commerce company. This system achieves three objectives: (a) Optimization of competing business objectives via Virtual Bids allowing the expressiveness of the valuation of the platform for these objectives. (b) Modeling the users' click behaviors considering explicitly the influence exerted by the sponsored and non-sponsored content displayed alongside through a deep learning approach. (c) Consideration of a Vickrey-Clarke-Groves (VCG) Auction design compatible with the allocation of ads and its induced externalities. Experiments are presented demonstrating the performance of the proposed system. Moreover, our approach is fully deployed and serves all traffic through JD.COM's mobile application.

MOTIVATION: Traditional Chinese medicine (TCM) is gaining increasing attention with the emergence of integrative medicine and personalized medicine, characterized by pattern differentiation on individual variance and treatments based on natural herbal synergism. Investigating the effectiveness and safety of the potential mechanisms of TCM and the combination principles of drug therapies will bridge the cultural gap with Western medicine and improve the development of integrative medicine. Dealing with rapidly growing amounts of biomedical data and their heterogeneous nature are two important tasks among modern biomedical communities. Bioinformatics, as an emerging interdisciplinary field of computer science and biology, has become a useful tool for easing the data deluge pressure by automating the computation processes with informatics methods. Using these methods to retrieve, store and analyze the biomedical data can effectively reveal the associated knowledge hidden in the data, and thus promote the discovery of integrated information. Recently, these techniques of bioinformatics have been used for facilitating the interactional effects of both Western medicine and TCM. The analysis of TCM data using computational technologies provides biological evidence for the basic understanding of TCM mechanisms, safety and efficacy of TCM treatments. At the same time, the carrier and targets associated with TCM remedies can inspire the rethinking of modern drug development. This review summarizes the significant achievements of applying bioinformatics techniques to many aspects of the research in TCM, such as analysis of TCM-related '-omics' data and techniques for analyzing biological processes and pharmaceutical mechanisms of TCM, which have shown certain potential of bringing new thoughts to both sides.

Linked data is a decentralized space of interlinked Resource Description Framework (RDF) graphs that are published, accessed, and manipulated by a multitude of Web agents. Here, we present a multi-agent framework for mining hypothetical semantic relations from linked data, in which the discovery, management, and validation of relations can be carried out independently by different agents. These agents collaborate in relation mining by publishing and exchanging inter-dependent knowledge elements, e.g., hypotheses, evidence, and proofs, giving rise to an evidentiary network that connects and ranks diverse knowledge elements. Simulation results show that the framework is scalable in a multi-agent environment. Real-world applications show that the framework is suitable for interdisciplinary and collaborative relation discovery tasks in social domains.