Due to the confined intraocular space and physical constraints in tool manipulation, snake-like robots have a significant potential for use in retinal microsurgery. By enhancing the dexterity at the tool tip, not only the operable space on the retina can be enlarged, but also the delicate target tissues can be reached at an optimal angle minimizing the damage and making the operation much easier. In this study, we present an improved version of our earlier integrated intraocular snake (IRIS) robot, and combine it with another robotic assistant: the cooperatively controlled Steady-Hand Eye Robot (SHER). SHER is used to drive IRIS close to the retina with precision, while IRIS makes omnidirectional bends by combining its yaw and pitch motions and provides a significantly enhanced intraocular dexterity while holding the sclerotomy port fixed. For precise control of IRIS, its snake-like tip actuation has been characterized through experiments considering both a free tool tip and external loading at the tool tip. The workspace analysis showed ±45° yaw and pitch with excellent repeatability (±1°) despite the highly miniaturized articulated segment length (3 mm) and very thin shaft (Ø 0.9 mm). Our preliminary experiments in an artificial eye model have shown feasibility in reaching targets requiring bends up to 55° accurately.

In retinal microsurgery, membrane peeling is a standard procedure requiring the delamination of a thin fibrous membrane adherent to the retina surface by applying very small forces. Robotic devices with combined force-sensing instruments have significant potential to assist this procedure by facilitating membrane delamination through induced micro-vibrations. However, defining the optimal frequency and amplitude for generating such vibrations, and updating these parameters during the procedure is not trivial. Automatic adjustment of these parameters via an adaptive control scheme is possible only if the individual parameter effects on delamination behavior are known. This study presents an experimental exploration of how micro-vibration amplitude and frequency affect membrane peeling forces alone. Combining a micromanipulator and a force-sensing micro-forceps, several peeling experiments were done on artificial phantoms (bandages) and inner shell membrane of raw chicken eggs. In the tested range of micro-vibration frequencies (10-50 Hz) the average delamination force was minimized mostly at 30 Hz for the bandages and at 50 Hz for the egg membranes. Increasing the micro-vibration amplitude from 50 μm up to 150 μm provided further reduction in average force, thus facilitated membrane delamination.

In vitreoretinal practice, controlled tremor-free motion and limitation of applied forces to the retina are two highly desired features. This study addresses both requirements with a new integrated system: a force-sensing motorized micro-forceps combined with an active tremor-canceling handheld micromanipulator, known as Micron. The micro-forceps is a 20 Ga instrument that is mechanically decoupled from its handle and senses the transverse forces at its tip with an accuracy of 0.3 mN. Membrane peeling trials on a bandage phantom revealed a 60-95% reduction in the 2-20 Hz band in both the tip force and position spectra, while peeling forces remained below the set safety threshold.

In vitreoretinal surgery, application of excessive forces and unintentional motion due to hand-tremor can easily result in serious complications. Robotic assistance when combined with tool-to-tissue force sensing capabilities has significant potential to improve such practice. In this paper, we evaluate the membrane peeling performance of a single user for two distinct robotic systems with integrated force sensing capabilities: Micron and the Steady-Hand Robot. We show that these systems provide promising performance improvement with similar impact on peeling forces and comparable tremor cancellation trends.

Highly accurate positioning is fundamental to the performance of vitreoretinal microsurgery. Of vitreoretinal procedures, membrane peeling is among the most prone to complications since extremely delicate manipulation of retinal tissue is required. Associated tool-to-tissue interaction forces are usually below the threshold of human perception, and the surgical tools are moved very slowly, within the 0.1-0.5 mm/s range. During the procedure, unintentional tool motion and excessive forces can easily give rise to vision loss or irreversible damage to the retina. A successful surgery includes two key features: controlled tremor-free tool motion and control of applied force. In this study, we present the potential benefits of a micro-force sensing robot in vitreoretinal surgery. Our main contribution is implementing fiber Bragg grating based force sensing in an active tremor canceling handheld micromanipulator, known as Micron, to measure tool-to-tissue interaction forces in real time. Implemented auditory sensory substitution assists in reducing and limiting forces. In order to test the functionality and performance, the force sensing Micron was evaluated in peeling experiments with adhesive bandages and with the inner shell membrane from chicken eggs. Our findings show that the combination of active tremor canceling together with auditory sensory substitution is the most promising aid that keeps peeling forces below 7 mN with a significant reduction in 2-20 Hz oscillations.

In virtual reality, some applications demand a fast, stable force response with high strength for use in haptic interfaces. While the existing active and passive actuators cannot fully satisfy these requirements alone, their cooperation could provide better results. This study aimed at the development of a hybrid actuator by combining a DC servomotor and a particle brake. The actuator was tested for multilayered tissue simulation, which required rendering abrupt changes and large forces. The designed controller adjusted the actuator inputs based on their capabilities. The brake provided an average force level while the motor superimposed the finer details on this profile. The hybrid actuator was able to track the force profile very well during virtual needle insertion and removal. It also provided a very rigid feeling when the needle touched the bone.