MOTIVATION: The Human cDNA Database (HCD) at the Institute for Genomic Research (TIGR) is the most complete, non-redundant and structured collection of human expressed DNA sequences available to date. Sequences and other data can be retrieved by users having opened an account at HCD/TIGR. A HCD search involves composing and sending queries one by one and this can become time consuming if many queries must be sent. Moreover, a large amount of time is required thereafter to process the results. RESULTS: The HCDSearch system described here automatically composes and sends the queries by e-mail using information provided in a text file; it also greatly accelerates the processing of results, generating lists of HCD numbers and library identifiers in a format that renders them very easy to examine. The programs run on Unix platforms.