Due to the expensive segmentation annotation cost, cross-modality medical image segmentation aims to leverage annotations from a source modality (e.g. MRI) to learn a model for target modality (e.g. CT). In this paper, we present a novel method to tackle cross-modality medical image segmentation as semi-supervised multi-modal learning with image translation, which learns better feature representations and is more robust to source annotation scarcity. For semi-supervised multi-modal learning, we develop a deep co-training framework. We address the challenges of co-training on divergent labeled and unlabeled data distributions with a theoretical analysis on multi-view adaptation and propose decomposed multi-view adaptation, which shows better performance than a naive adaptation method on concatenated multi-view features. We further formulate inter-view regularization to alleviate overfitting in deep networks, which regularizes deep co-training networks to be compatible with the underlying data distribution. We perform extensive experiments to evaluate our framework. Our framework significantly outperforms state-of-the-art domain adaptation methods on three segmentation datasets, including two public datasets on cross-modality cardiac substructure segmentation and abdominal multi-organ segmentation and one large scale private dataset on cross-modality brain tissue segmentation. Our code is publicly available at https://github.com/zlheui/DCT.

In this paper, we propose a novel semi-supervised learning (SSL) framework named BoostMIS that combines adaptive pseudo labeling and informative active annotation to unleash the potential of medical image SSL models: (1) BoostMIS can adaptively leverage the cluster assumption and consistency regularization of the unlabeled data according to the current learning status. This strategy can adaptively generate one-hot “hard” labels converted from task model predictions for better task model training. (2) For the unselected unlabeled images with low confidence, we introduce an Active learning (AL) algorithm to find the informative samples as the annotation candidates by exploiting virtual adversarial perturbation and model's density-aware entropy. These informative candidates are subsequently fed into the next training cycle for better SSL label propagation. Notably, the adaptive pseudo-labeling and informative active annotation form a learning closed-loop that are mutually collaborative to boost medical image SSL. To verify the effectiveness of the proposed method, we collected a metastatic epidural spinal cord compression (MESCC) dataset that aims to optimize MESCC diagnosis and classification for improved specialist referral and treatment. We conducted an extensive experimental study of BoostMIS on MESCC dataset. The experimental results verify our framework's effectiveness with a significant improvement over various state-of-the-art methods. Our work will be available at github11https://github.com/wannature/BoostMIS.

Static malware detection is important for protection against malware by allowing for malicious files to be detected prior to execution. It is also especially suitable for machine learning-based approaches. Recently, gradient boosting decision trees (GBDT) models, e.g., LightGBM (a popular implementation of GBDT), have shown outstanding performance for malware detection. However, as malware programs are known to evolve rapidly, malware classification models trained on the (source) training data often fail to generalize to the target domain, i.e., the deployed environment. To handle the underlying data distribution drifts, unsupervised domain adaptation techniques have been proposed for machine learning models including deep learning models. However, unsupervised domain adaptation for GBDT has remained challenging. In this paper, we adapt the adversarial learning framework for unsupervised domain adaptation to enable GBDT learn domain-invariant features and alleviate performance degradation in the target domain. In addition, to fully exploit the unlabelled target data, we merge them into the training dataset after pseudo-labelling. We propose a new weighting scheme integrated into GBDT for sampling instances in each boosting round to reduce the negative impact of wrongly labelled target instances. Experiments on two large malware datasets demonstrate the superiority of our proposed method.

With the ever-increasing adoption of machine learning for data analytics, maintaining a machine learning pipeline is becoming more complex as both the datasets and trained models evolve with time. In a collaborative environment, the changes and updates due to pipeline evolution often cause cumbersome coordination and maintenance work, raising the costs and making it hard to use. Existing solutions, unfortunately, do not address the version evolution problem, especially in a collaborative environment where non-linear version control semantics are necessary to isolate operations made by different user roles. The lack of version control semantics also incurs unnecessary storage consumption and lowers efficiency due to data duplication and repeated data pre-processing, which are avoidable.In this paper, we identify two main challenges that arise during the deployment of machine learning pipelines, and address them with the design of versioning for an end-to-end analytics system MLCask. The system supports multiple user roles with the ability to perform Git-like branching and merging operations in the context of the machine learning pipelines. We define and accelerate the metric-driven merge operation by pruning the pipeline search tree using reusable history records and pipeline compatibility information. Further, we design and implement the prioritized pipeline search, which gives preference to the pipelines that probably yield better performance. The effectiveness of MLCask is evaluated through an extensive study over several real-world deployment cases. The performance evaluation shows that the proposed merge operation is up to 7.8x faster and saves up to 11.9x storage space than the baseline method that does not utilize history records.

Deep learning has made a tremendous impact on various applications in multimedia, such as media interpretation and multimodal retrieval. However, deep learning models usually require a large amount of labeled data to achieve satisfactory performance. In multimedia analysis, domain adaptation studies the problem of cross-domain knowledge transfer from a label rich source domain to a label scarce target domain, thus potentially alleviates the annotation requirement for deep learning models. However, we find that contemporary domain adaptation methods for cross-domain image understanding perform poorly when source domain is noisy. Weakly Supervised Domain Adaptation (WSDA) studies the domain adaptation problem under the scenario where source data can be noisy. Prior methods on WSDA remove noisy source data and align the marginal distribution across domains without considering the fine-grained semantic structure in the embedding space, which have the problem of class misalignment, e.g., features of cats in the target domain might be mapped near features of dogs in the source domain. In this paper, we propose a novel method, termed Noise Tolerant Domain Adaptation (NTDA), for WSDA. Specifically, we adopt the cluster assumption and learn cluster discriminatively with class prototypes (centroids) in the embedding space. We propose to leverage the location information of the data points in the embedding space and model the location information with a Gaussian mixture model to identify noisy source data. We then design a network which incorporates the Gaussian mixture noise model as a sub-module for unsupervised noise removal and propose a novel cluster-level adversarial adaptation method based on the Generative Adversarial Network (GAN) framework which aligns unlabeled target data with the less noisy class prototypes for mapping the semantic structure across domains. Finally, we devise a simple and effective algorithm to train the network from end to end. We conduct extensive experiments to evaluate the effectiveness of our method on both general images and medical images from COVID-19 and e-commerce datasets. The results show that our method significantly outperforms state-of-the-art WSDA methods.