Gait analysis is crucial for the diagnosis and monitoring of movement disorders like Parkinson's Disease. While computer vision models have shown potential for objectively evaluating parkinsonian gait, their effectiveness is limited by scarce clinical datasets and the challenge of collecting large and well-labelled data, impacting model accuracy and risk of bias. To address these gaps, we propose GAITGen, a novel framework that generates realistic gait sequences conditioned on specified pathology severity levels. GAITGen employs a Conditional Residual Vector Quantized Variational Autoencoder to learn disentangled representations of motion dynamics and pathology-specific factors, coupled with Mask and Residual Transformers for conditioned sequence generation. GAITGen generates realistic, diverse gait sequences across severity levels, enriching datasets and enabling large-scale model training in parkinsonian gait analysis. Experiments on our new PD-GaM (real) dataset demonstrate that GAITGen outperforms adapted state-of-the-art models in both reconstruction fidelity and generation quality, accurately capturing critical pathology-specific gait features. A clinical user study confirms the realism and clinical relevance of our generated sequences. Moreover, incorporating GAITGen-generated data into downstream tasks improves parkinsonian gait severity estimation, highlighting its potential for advancing clinical gait analysis.

Automated facial expression quality assessment (FEQA) in neurological disorders is critical for enhancing diagnostic accuracy and improving patient care, yet effectively capturing the subtle motions and nuances of facial muscle movements remains a challenge. We propose to analyse facial landmark trajectories, a compact yet informative representation, that encodes these subtle motions from a high-level structural perspective. Hence, we introduce Trajectory-guided Motion Perception Transformer (TraMP-Former), a novel FEQA framework that fuses landmark trajectory features for fine-grained motion capture with visual semantic cues from RGB frames, ultimately regressing the combined features into a quality score. Extensive experiments demonstrate that TraMP-Former achieves new state-of-the-art performance on bench-mark datasets with neurological disorders, including PFED5 ($\uparrow$ $6.51 \%$) and an augmented Toronto NeuroFace ($\uparrow 7.62 \%$). Our ablation studies further validate the efficiency and effectiveness of landmark trajectories in FEQA. Our code is available at https://github.com/shuchaoduan/TraMP-Former.

Objective gait assessment in Parkinson’s Disease (PD) is limited by the absence of large, diverse, and clinically annotated motion datasets. We introduce Care-PD, the largest publicly available archive of 3D mesh gait data for PD, and the first multi-site collection spanning 9 cohorts from 8 clinical centers. All recordings (RGB video or motion capture) are converted into anonymized SMPL meshes via a harmonized preprocessing pipeline. Care-PD supports two key benchmarks: supervised clinical score prediction (estimating Unified Parkinson’s Disease Rating Scale, UPDRS, gait scores) and unsupervised motion pretext tasks (2D-to-3D keypoint lifting and full-body 3D reconstruction). Clinical prediction is evaluated under four generalization protocols: within-dataset, cross-dataset, leave-one-dataset-out, and multi-dataset in-domain adaptation.To assess clinical relevance, we compare state-of-the-art motion encoders with a traditional gait-feature baseline, finding that encoders consistently outperform handcrafted features. Pretraining on Care-PD reduces MPJPE (from 60.8mm to 7.5mm) and boosts PD severity macro-F1 by 17\%, underscoring the value of clinically curated, diverse training data. Care-PD and all benchmark code are released for non-commercial research (Code, Data).

People with Parkinson's Disease (PD) often experience progressively worsening gait, including changes in how they turn around, as the disease progresses. Existing clinical rating tools are not capable of capturing hour-by-hour variations of PD symptoms, as they are confined to brief assessments within clinic settings, leaving gait performance outside these controlled environments unaccounted for. Measuring turning angles continuously and passively is a component step towards using gait characteristics as sensitive indicators of disease progression in PD. This paper presents a deep learning-based approach to automatically quantify turning angles by extracting 3D skeletons from videos and calculating the rotation of hip and knee joints. We utilise advanced human pose estimation models, Fastpose and Strided Transformer, on a total of 1386 turning video clips from 24 subjects (12 people with PD and 12 healthy control volunteers), trimmed from a PD dataset of unscripted free-living videos in a home-like setting (Turn-REMAP). We also curate a turning video dataset, Turn-H3.6M, from the public Human3.6M human pose benchmark with 3D groundtruth, to further validate our method. Previous gait research has primarily taken place in clinics or laboratories evaluating scripted gait outcomes, but this work focuses on free-living home settings where complexities exist, such as baggy clothing and poor lighting. Due to difficulties in obtaining accurate groundtruth data in a free-living setting, we quantise the angle into the nearest bin 45° based on the manual labelling of expert clinicians. Our method achieves a turning calculation accuracy of 41.6%, a Mean Absolute Error (MAE) of 34.7°, and a weighted precision (WPrec) of 68.3% for Turn-REMAP. On Turn-H3.6M, it achieves an accuracy of 73.5%, an MAE of 18.5°, and a WPrec of 86.2%. This is the first work to explore the use of single monocular camera data to quantify turns by PD patients in a home setting. All data and models are publicly available, providing a baseline for turning parameter measurement to promote future PD gait research.

The limited availability of labelled data in Action Quality Assessment (AQA), has forced previous works to fine-tune their models pretrained on large-scale domain-general datasets. This common approach results in weak generalisation, particularly when there is a significant domain shift. We propose a novel, parameter efficient, continual pretraining framework, PECoP, to reduce such domain shift via an additional pretraining stage. In PECoP, we introduce 3D-Adapters, inserted into the pretrained model, to learn spatiotemporal, in-domain information via self-supervised learning where only the adapter modules’ parameters are updated. We demonstrate PECoP’s ability to enhance the performance of recent state-of-the-art methods (MUSDL, CoRe, and TSA) applied to AQA, leading to considerable improvements on benchmark datasets, JIGSAWS (↑ 6.0%), MTL-AQA (↑ 0.99%), and FineDiving (↑ 2.54%). We also present a new Parkinson’s Disease dataset, PD4T, of real patients performing four various actions, where we surpass (↑ 3.56%) the state-of-the-art in comparison. Our code, pretrained models, and the PD4T dataset are available at https://github.com/Plrbear/PECoP.

Parkinson's Disease (PD) is the second most common neurodegenerative disease and prevalence is increasing as populations age. However, because it remains difficult to sensitively evaluate symptom progression, testing of therapies which change the disease course has been hampered (and no such therapy is yet licensed). The more recent use of home monitoring systems provides the potential for providing granular assessment of symptom progression, specifically, tremor evaluation, by continuous monitoring using inertial measurement units. A significant barrier remains in obtaining the ground truth information to assess inference models in these non-laboratory environments. Given these limitations, in this paper we propose a machine learning tremor regression model and classifier heuristic that uses minimal annotations. We use a real-world dataset of 12 participants, where pairs of participants, one with PD and a healthy control, are monitored over a four-day period in a home environment with wrist-worn devices. Our approach leverages the accelerometer frequency-time representation. We evaluate the classifier heuristic on the control participants. The tremor score regression model is trained on the self-assessments of the participants. We show that the tremor classifier can achieve false positive rates (FPR) less than 0.001 (on average one false positive every five hours) on control participants. For a particular participant, we show that the machine learning regression model achieves a mean absolute error (MAE) of 0.46 as compared to a polynomial regression model (degree=3) with MAE of 0.99. This research is the first to provide a semi-supervised machine learning approach using self-report of symptoms to continually predict tremor scores for individuals with PD.

Parkinson's disease (PD) is a slowly progressive, debilitating neurodegenerative disease which causes motor symptoms including gait dysfunction. Motor fluctuations are alterations between periods with a positive response to levodopa therapy ("on") and periods marked by re-emergency of PD symptoms ("off") as the response to medication wears off. These fluctuations often affect gait speed and they increase in their disabling impact as PD progresses. To improve the effectiveness of current indoor localisation methods, a transformer-based approach utilising dual modalities which provide complementary views of movement, Received Signal Strength Indicator (RSSI) and accelerometer data from wearable devices, is proposed. A sub-objective aims to evaluate whether indoor localisation, including its in-home gait speed features (i.e. the time taken to walk between rooms), could be used to evaluate motor fluctuations by detecting whether the person with PD is taking levodopa medications or withholding them. To properly evaluate our proposed method, we use a free-living dataset where the movements and mobility are greatly varied and unstructured as expected in real-world conditions. 24 participants lived in pairs (consisting of one person with PD, one control) for five days in a smart home with various sensors. Our evaluation on the resulting dataset demonstrates that our proposed network outperforms other methods for indoor localisation. The sub-objective evaluation shows that precise room-level localisation predictions, transformed into in-home gait speed features, produce accurate predictions on whether the PD participant is taking or withholding their medications.

In interdisciplinary spaces such as digital health, datasets that are complex to collect, require specialist facilities, and/or are collected with specific populations have value in a range of different sectors. In this study we collected a simulated free-living dataset, in a smart home, with 12 participants (six people with Parkinson’s, six carers). We explored their initial perceptions of the sensors through interviews and then conducted two data exploration workshops, wherein we showed participants the collected data and discussed their views on how this data, and other data relating to their Parkinson’s symptoms, might be shared across different sectors. We provide recommendations around how participants might be better engaged in considering data sharing in the early stages of research, and guidance for how research might be configured to allow for more informed data sharing practices in the future.

Evaluating neurological disorders such as Parkinson's disease (PD) is a challenging task that requires the assessment of several motor and non-motor functions. In this paper, we present an end-to-end deep learning framework to measure PD severity in two important components, hand movement and gait, of the Unified Parkinson's Disease Rating Scale (UPDRS). Our method leverages on an Inflated 3D CNN trained by a temporal segment framework to learn spatial and long temporal structure in video data. We also deploy a temporal attention mechanism to boost the performance of our model. Further, motion boundaries are explored as an extra input modality to assist in obfuscating the effects of camera motion for better movement assessment. We ablate the effects of different data modalities on the accuracy of the proposed network and compare with other popular architectures. We evaluate our proposed method on a dataset of 25 PD patients, obtaining 72.3% and 77.1% top-1 accuracy on hand movement and gait tasks respectively.