Time series forecasting, as one of the fundamental machine learning areas, has attracted tremendous attentions over recent years. The solutions have evolved from statistical machine learning (ML) methods to deep learning techniques. One emerging sub-field of time series forecasting is individual disease progression forecasting, e.g., predicting individuals' disease development over a few days (e.g., deteriorating trends, recovery speed) based on few past observations. Despite the promises in the existing ML techniques, a variety of unique challenges emerge for disease progression forecasting, such as irregularly-sampled time series, data sparsity, and individual heterogeneity in disease progression. To tackle these challenges, we propose novel Conditional Neural Ordinary Differential Equations Processes (CNDPs), and validate it in a COVID-19 disease progression forecasting task using audio data. CNDPs allow for irregularly-sampled time series modelling, enable accurate forecasting with sparse past observations, and achieve individual-level progression forecasting. CNDPs show strong performance with an Unweighted Average Recall (UAR) of 78.1%, outperforming a variety of commonly used Recurrent Neural Networks based models. With the proposed label-enhancing mechanism (i.e., including the initial health status as input) and the customised individual-level loss, CNDPs further boost the performance reaching a UAR of 93.6%. Additional analysis also reveals the model's capability in tracking individual-specific recovery trend, implying the potential usage of the model for remote disease progression monitoring. In general, CNDPs pave new pathways for time series forecasting, and provide considerable advantages for disease progression monitoring.

The development of fast and accurate screening tools, which could facilitate testing and prevent more costly clinical tests, is key to the current pandemic of COVID-19. In this context, some initial work shows promise in detecting diagnostic signals of COVID-19 from audio sounds. In this paper, we propose a voice-based framework to automatically detect individuals who have tested positive for COVID-19. We evaluate the performance of the proposed framework on a subset of data crowdsourced from our app, containing 828 samples from 343 participants. By combining voice signals and reported symptoms, an AUC of 0.79 has been attained, with a sensitivity of 0.68 and a specificity of 0.82. We hope that this study opens the door to rapid, low-cost, and convenient pre-screening tools to automatically detect the disease.

The INTERSPEECH 2021 Computational Paralinguistics Challenge addresses four different problems for the first time in a research competition under well-defined conditions: In the COVID-19 Cough and COVID-19 Speech Sub-Challenges, a binary classification on COVID-19 infection has to be made based on coughing sounds and speech; in the Escalation SubChallenge, a three-way assessment of the level of escalation in a dialogue is featured; and in the Primates Sub-Challenge, four species vs background need to be classified. We describe the Sub-Challenges, baseline feature extraction, and classifiers based on the 'usual' COMPARE and BoAW features as well as deep unsupervised representation learning using the AuDeep toolkit, and deep feature extraction from pre-trained CNNs using the Deep Spectrum toolkit; in addition, we add deep end-to-end sequential modelling, and partially linguistic analysis.

Earables (in-ear wearables) are a new frontier in wearables. Acting both as leisure devices, providing personal audio, as well as sensing platforms, earables could collect sensor data for the upper part of the body, subject to fewer vibrations and random movement variations than the lower parts of the body, due to inherent damping in the musculoskeletal system. These data may enable application domains such as augmented/virtual reality, medical rehabilitation, and health condition screening. Unfortunately, earables have inherent size, shape, and weight constraints limiting the type and position of the sensors on such platforms. For instance, lacking a magnetometer in all earables reference platforms, earables lack reference points. Thus, it becomes harder to work with absolute orientations. Embedding magnetometers in earables is challenging, as these rely heavily on radio (mostly Bluetooth) communication (RF) and contain magnets for magnetic-driven speakers and docking. We explore the feasibility of adding a built-in magnetometer in an earbud, presenting the first comprehensive study of the magnetic interference impacting the magnetometer when placed in an earable: both that caused by the speaker and by RF (music streaming and voice calls) are considered. We find that appropriate calibration of the magnetometer removes the offsets induced by the magnets, the speaker, and the variable interference due to BT. Further, we present an automatic, user-transparent adaptive calibration that obviates the need for alternative, expensive, and error-prone manual, or robotics, calibration procedures. Our evaluation shows how our calibration approach performs under different conditions, achieving convincing results with errors below 3° for the majority of the experiments.

Audio signals generated by the human body (e.g., sighs, breathing, heart, digestion, vibration sounds) have routinely been used by clinicians as indicators to diagnose disease or assess disease progression. Until recently, such signals were usually collected through manual auscultation at scheduled visits. Research has now started to use digital technology to gather bodily sounds (e.g., from digital stethoscopes) for cardiovascular or respiratory examination, which could then be used for automatic analysis. Some initial work shows promise in detecting diagnostic signals of COVID-19 from voice and coughs. In this paper we describe our data analysis over a large-scale crowdsourced dataset of respiratory sounds collected to aid diagnosis of COVID-19. We use coughs and breathing to understand how discernible COVID-19 sounds are from those in asthma or healthy controls. Our results show that even a simple binary machine learning classifier is able to classify correctly healthy and COVID-19 sounds. We also show how we distinguish a user who tested positive for COVID-19 and has a cough from a healthy user with a cough, and users who tested positive for COVID-19 and have a cough from users with asthma and a cough. Our models achieve an AUC of above 80% across all tasks. These results are preliminary and only scratch the surface of the potential of this type of data and audio-based machine learning. This work opens the door to further investigation of how automatically analysed respiratory patterns could be used as pre-screening signals to aid COVID-19 diagnosis.

We present a federated, asynchronous, and $(\varepsilon, \delta)$-differentially private algorithm for $\PCA$ in the memory-limited setting. % Our algorithm incrementally computes local model updates using a streaming procedure and adaptively estimates its $r$ leading principal components when only $\mathcal{O}(dr)$ memory is available with $d$ being the dimensionality of the data. % We guarantee differential privacy via an input-perturbation scheme in which the covariance matrix of a dataset $\B{X} \in \R^{d \times n}$ is perturbed with a non-symmetric random Gaussian matrix with variance in $\mathcal{O}\left(\left(\frac{d}{n}\right)^2 \log d \right)$, thus improving upon the state-of-the-art. % Furthermore, contrary to previous federated or distributed algorithms for $\PCA$, our algorithm is also invariant to permutations in the incoming data, which provides robustness against straggler or failed nodes. % Numerical simulations show that, while using limited-memory, our algorithm exhibits performance that closely matches or outperforms traditional non-federated algorithms, and in the absence of communication latency, it exhibits attractive horizontal scalability.

This paper introduces Memory-limited Online Subspace Estimation Scheme (MOSES) for both estimating the principal components of streaming data and reducing its dimension. More specifically, in various applications such as sensor networks, the data vectors are presented sequentially to a user who has limited storage and processing time available. Applied to such problems, MOSES can provide a running estimate of leading principal components of the data that has arrived so far and also reduce its dimension. MOSES generalises the popular incremental Singular Vale Decomposition (iSVD) to handle thin blocks of data, rather than just vectors. This minor generalisation in part allows us to complement MOSES with a comprehensive statistical analysis, thus providing the first theoretically-sound variant of iSVD, which has been lacking despite the empirical success of this method. This generalisation also enables us to concretely interpret MOSES as an approximate solver for the underlying non-convex optimisation program. We find that MOSES consistently surpasses the state of the art in our numerical experiments with both synthetic and real-world datasets, while being computationally inexpensive.