Individuals with Opioid Use Disorder (OUD) often struggle to maintain sobriety, with many experiencing relapse within the first year. While medication-assisted treatment (MAT) is among the most effective approaches, access to intensive care is often limited by financial barriers. Mobile health (mHealth) technologies offer a promising, cost-effective alternative by enabling continuous monitoring and timely intervention through tools such as ecological momentary assessments (EMAs), wearable sensors, and smartphone data. In this study, we explore the feasibility of using mHealth data to predict emotions that align with cravings in OUD patients undergoing MAT. Using data collected from EMAs, wearables, smartphone tracking, and surveys, we demonstrate that machine learning models can accurately predict emotional states associated with cravings. These findings highlight the potential of mHealth systems to support individuals with OUD through timely and scalable interventions.

Psychomotor retardation in depression has been associated with speech timing changes from dyadic clinical interviews.In this work, we investigate speech timing features from freeliving dyadic interactions.Apart from the possibility of continuous monitoring to complement clinical visits, a study in free-living conditions would also allow inferring sociability features such as dyadic interaction frequency implicated in depression.We adapted a speaker count estimator as a dyadic interaction detector with a specificity of 89.5% and a sensitivity of 86.1% in the DIHARD dataset.Using the detector, we obtained speech timing features from the detected dyadic interactions in multi-day audio recordings of 32 participants comprised of 13 healthy individuals, 11 individuals with depression, and 8 individuals with psychotic disorders.The dyadic interaction frequency increased with depression severity in participants with no or mild depression, indicating a potential diagnostic marker of depression onset.However, the dyadic interaction frequency decreased with increasing depression severity for participants with moderate or severe depression.In terms of speech timing features, the response time had a significant positive correlation with depression severity.Our work shows the potential of dyadic interaction analysis from audio recordings of free-living to obtain markers of depression severity.

With the rise of ever-more sophisticated wearables and sensing technologies, mobile health continues to be an active area of research. However, from a clinical researcher point of view, testing novel use of the mobile health innovations remains a major hurdle, as composing a clinical trial using a combination of technologies still remains in the realm of computer scientists. We take a software-inspired viewpoint of clinical trial designs to design, develop and validate HealthSense to enable expressibility of complex ideas, composability with diverse devices and services while maximally maintaining simplicity for a clinical research user. A key innovation in HealthSense is the concept of a study state manager (SSM) that modifies parameters of the study over time as data accumulates and can trigger external events that affect the participant; this design allows us to implement nearly arbitrary clinical trial designs. The SSM can funnel data streams to custom or third-party cloud processing pipelines and the result can be used to give interventions and modify parameters of the study. HealthSense supports both Android and iOS platforms and is secure, scalable and fully operational. We outline three trials (two with clinical populations) to highlight simplicity, composability, and expressibility of HealthSense.