Gait analysis is crucial for the diagnosis and monitoring of movement disorders like Parkinson's Disease. While computer vision models have shown potential for objectively evaluating parkinsonian gait, their effectiveness is limited by scarce clinical datasets and the challenge of collecting large and well-labelled data, impacting model accuracy and risk of bias. To address these gaps, we propose GAITGen, a novel framework that generates realistic gait sequences conditioned on specified pathology severity levels. GAITGen employs a Conditional Residual Vector Quantized Variational Autoencoder to learn disentangled representations of motion dynamics and pathology-specific factors, coupled with Mask and Residual Transformers for conditioned sequence generation. GAITGen generates realistic, diverse gait sequences across severity levels, enriching datasets and enabling large-scale model training in parkinsonian gait analysis. Experiments on our new PD-GaM (real) dataset demonstrate that GAITGen outperforms adapted state-of-the-art models in both reconstruction fidelity and generation quality, accurately capturing critical pathology-specific gait features. A clinical user study confirms the realism and clinical relevance of our generated sequences. Moreover, incorporating GAITGen-generated data into downstream tasks improves parkinsonian gait severity estimation, highlighting its potential for advancing clinical gait analysis.

Objective gait assessment in Parkinson’s Disease (PD) is limited by the absence of large, diverse, and clinically annotated motion datasets. We introduce Care-PD, the largest publicly available archive of 3D mesh gait data for PD, and the first multi-site collection spanning 9 cohorts from 8 clinical centers. All recordings (RGB video or motion capture) are converted into anonymized SMPL meshes via a harmonized preprocessing pipeline. Care-PD supports two key benchmarks: supervised clinical score prediction (estimating Unified Parkinson’s Disease Rating Scale, UPDRS, gait scores) and unsupervised motion pretext tasks (2D-to-3D keypoint lifting and full-body 3D reconstruction). Clinical prediction is evaluated under four generalization protocols: within-dataset, cross-dataset, leave-one-dataset-out, and multi-dataset in-domain adaptation.To assess clinical relevance, we compare state-of-the-art motion encoders with a traditional gait-feature baseline, finding that encoders consistently outperform handcrafted features. Pretraining on Care-PD reduces MPJPE (from 60.8mm to 7.5mm) and boosts PD severity macro-F1 by 17\%, underscoring the value of clinically curated, diverse training data. Care-PD and all benchmark code are released for non-commercial research (Code, Data).

Parkinson's Disease is a degenerative disorder for which precise motor assessment is critical. This study investigates the application of general human motion encoders trained on large-scale human motion datasets for analyzing gait patterns in PD patients. Although these models have learned a wealth of human biomechanical knowledge, their effectiveness in analyzing pathological movements, such as parkinsonian gait, has yet to be fully validated. We propose a comparative framework and evaluate six pre-trained state-of-the-art human motion encoder models on their ability to predict the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS-III) gait scores from motion capture data. We compare these against a traditional gait feature-based predictive model in a recently released large public PD dataset, including PD patients on and off medication. The feature-based model currently shows higher weighted average accuracy, precision, recall, and F1-score. Motion encoder models with closely comparable results demonstrate promise for scalability and efficiency in clinical settings. This potential is underscored by the enhanced performance of the encoder model upon fine-tuning on PD training set. Four of the six human motion models examined provided prediction scores that were significantly different between on- and off-medication states. This finding reveals the sensitivity of motion encoder models to nuanced clinical changes, emphasizing their potential utility in clinical settings. It also underscores the necessity for continued customization of these models to better capture disease-specific features, thereby reducing the reliance on labor-intensive feature engineering. Lastly, we establish a benchmark for the analysis of skeleton-based motion encoder models in clinical settings. To the best of our knowledge, this is the first study to provide a benchmark that enables state-of-the-art models to be tested and compete in a clinical context. Codes and benchmark leaderboard are available at code.

Recent transformer-based approaches have demonstrated excellent performance in 3D human pose estimation. However, they have a holistic view and by encoding global relationships between all the joints, they do not capture the local dependencies precisely. In this paper, we present a novel Attention-GCNFormer (AGFormer) block that divides the number of channels by using two parallel transformer and GCNFormer streams. Our proposed GCNFormer module exploits the local relationship between adjacent joints, outputting a new representation that is complementary to the transformer output. By fusing these two representation in an adaptive way, AGFormer exhibits the ability to better learn the underlying 3D structure. By stacking multiple AGFormer blocks, we propose MotionAGFormer in four different variants, which can be chosen based on the speed-accuracy trade-off. We evaluate our model on two popular benchmark datasets: Human3.6M and MPI-INF-3DHP. MotionAGFormer-B achieves state-of-the-art results, with P1 errors of 38.4 mm and 16.2 mm, respectively. Remarkably, it uses a quarter of the parameters and is three times more computationally efficient than the previous leading model on Human3.6M dataset. Code and models are available at https://github.com/TaatiTeam/MotionAGFormer.

Falls are a leading cause of morbidity and mortality in older adults with dementia residing in long-term care. Having access to a frequently updated and accurate estimate of the likelihood of a fall over a short time frame for each resident will enable care staff to provide targeted interventions to prevent falls and resulting injuries. To this end, machine learning models to estimate and frequently update the risk of a fall within the next 4 weeks were trained on longitudinal data from 54 older adult participants with dementia. Data from each participant included baseline clinical assessments of gait, mobility, and fall risk at the time of admission, daily medication intake in three medication categories, and frequent assessments of gait performed via a computer vision-based ambient monitoring system. Systematic ablations investigated the effects of various hyperparameters and feature sets and experimentally identified differential contributions from baseline clinical assessments, ambient gait analysis, and daily medication intake. In leave-one-subject-out cross-validation, the best performing model predicts the likelihood of a fall over the next 4 weeks with a sensitivity and specificity of 72.8 and 73.2, respectively, and achieved an area under the receiver operating characteristic curve (AUROC) of 76.2. By contrast, the best model excluding ambient gait features achieved an AUROC of 56.2 with a sensitivity and specificity of 51.9 and 54.0, respectively. Future research will focus on externally validating these findings to prepare for the implementation of this technology to reduce fall and fall-related injuries in long-term care.

Joint forecasting of human trajectory and pose dynamics is a fundamental building block of various applications ranging from robotics and autonomous driving to surveillance systems. Predicting body dynamics requires capturing subtle information embedded in the humans’ interactions with each other and with the objects present in the scene. In this paper, we propose a novel TRajectory and POse Dynamics (nicknamed TRiPOD) method based on graph attentional networks to model the human-human and human-object interactions both in the input space and the output space (decoded future output). The model is supplemented by a message passing interface over the graphs to fuse these different levels of interactions efficiently. Furthermore, to incorporate a real-world challenge, we propound to learn an indicator representing whether an estimated body joint is visible/invisible at each frame, e.g. due to occlusion or being outside the sensor field of view. Finally, we introduce a new benchmark for this joint task based on two challenging datasets (PoseTrack and 3DPW) and propose evaluation metrics to measure the effectiveness of predictions in the global space, even when there are invisible cases of joints. Our evaluation shows that TRiPOD outperforms all prior work and state-of-the-art specifically designed for each of the trajectory and pose forecasting tasks.