Traditional video reasoning segmentation methods rely on supervised fine-tuning, which limits generalization to out-of-distribution scenarios and lacks explicit reasoning. To address this, we propose VideoSeg-R1, the first framework to introduce reinforcement learning into video reasoning segmentation. It adopts a decoupled architecture that formulates the task as joint referring image segmentation and video mask propagation. It comprises three stages: (1) A hierarchical text-guided frame sampler to emulate human attention; (2) A reasoning model that produces spatial cues along with explicit reasoning chains; and (3) A segmentation-propagation stage using SAM2 and XMem. A task difficulty-aware mechanism adaptively controls reasoning length for better efficiency and accuracy. Extensive evaluations on multiple benchmarks demonstrate that VideoSeg-R1 achieves state-of-the-art performance in complex video reasoning and segmentation tasks.

ABSTRACT Cyber‐Physical‐Social System (CPSS) which refers to the complex interaction of cyber, physical and social systems, has the important purpose to provide personalized intelligent services. CPSS data, generated from every aspect of people living life, are mainly in the form of time series multimodal data with characteristic of high order and high dimension. How to efficiently process these CPSS data is one of the fundamental ways for the intelligent services. In this paper, a highly‐efficient attention driven Quantized Tensor Train Recursive Neural Network is proposed, in which the CPSS data is decomposed into the form of tensor train cores. In this way, the proposed method is composed of lightweight high‐order neural network units, which better preserves the multi‐attribute features of the original data and the correlation between different dimensions by using tensors with its calculations, and implicitly trims the dense vector‐matrix connections in the fully connected network by using the form of quantization tensor train decomposition, which greatly reduces the model parameters, shortens the training time and improves the efficiency. Also, an effective attentional feature enhancement module is constructed to assist the high‐order neural network, so that the overall model can achieve a balance between low parameter number and accuracy. The network structure proposed in this paper realizes an efficient and lossless high‐order tensor recurrent neural network model with a small number of parameters. Finally, experiments on the UCF50 action video dataset, CWRU bearing dataset, and image generation tasks are conducted. Comparative analyses with vanilla LSTM and other tensorized LSTMs in terms of training time, accuracy, error, and compression ratio validate the reliability of the proposed model.

Recognizing speaker intent in long audio dialogues among speakers has a wide range of applications, but is a non-trivial AI task due to complex inter-dependencies in speaker utterances and scarce annotated data. To address these challenges, an end-to-end framework, namely DialogGraph-LLM, is proposed in the current work. DialogGraph-LLM combines a novel Multi-Relational Dialogue Attention Network (MR-DAN) architecture with multimodal foundation models (e.g., Qwen2.5-Omni-7B) for direct acoustic-to-intent inference. An adaptive semi-supervised learning strategy is designed using LLM with a confidence-aware pseudo-label generation mechanism based on dual-threshold filtering using both global and class confidences, and an entropy-based sample selection process that prioritizes high-information unlabeled instances. Extensive evaluations on the proprietary MarketCalls corpus and the publicly available MIntRec 2.0 benchmark demonstrate DialogGraph-LLM’s superiority over strong audio and text-driven baselines. The framework demonstrates strong performance and efficiency in intent recognition in real world scenario audio dialogues, proving its practical value for audio-rich domains with limited supervision. Our code is available at https://github.com/david188888/DialogGraph-LLM

Enhancing antibody affinity is a critical goal in antibody design, as it improves therapeutic efficacy, specificity, and safety while reducing dosage requirements. Traditional methods, such as single-point mutations or combinatorial mutagenesis, are limited by the impracticality of exhaustively exploring the vast mutational space. To address this challenge, we developed a novel computational pipeline that integrates evolutionary constraints, antibody-antigen-specific statistical potentials, molecular dynamics simulations, metadynamics, and a suite of deep learning models to identify affinity-enhancing mutations. Our deep learning framework includes MicroMutate, which predicts microenvironment-specific amino acid mutations, and graph-based models that evaluate postmutation antigen-antibody-binding probabilities. Using this approach, we screened 12 single-point mutant antibodies targeting the hemagglutinin of the H7N9 avian influenza virus, starting from antibodies with initial affinities in the subnanomolar range, with one showing a 4.62-fold improvement. To demonstrate the generalizability of our method, we applied it to engineer an antibody against death receptor 5 with initial affinities in the subnanomolar range, successfully identifying a mutant with a 2.07-fold increase in affinity. Our work underscores the transformative potential of integrating deep learning and computational methods for rapidly and precisely discovering affinity-enhancing mutations while preserving immunogenicity and expression. This approach offers a powerful and universal platform for advancing antibody therapeutics.

The image enhancement task requires a complex balance between extracting high-level contextual information and optimizing spatial details in the image to improve the visual quality. Most of existing methods have limited capability in capturing contextual features and optimizing spatial details when they only rely on a single modality. To address the above issues, this paper introduces a novel multi-modal image enhancement network based on Transformer, named as TITFormer, which combines textual and simulating infrared modalities firstly for this important task. TITFormer comprises a text channel attention fusion (TCF) network block and an infrared-guided spatial detail optimization (SDO) network block. The TCF extracts contextual features from the high-dimensional features compressed after spatial channel transformation of the textual feature and image feature. The SDO module uses simulating infrared images characterized by pixel intensity to guide the optimization of spatial details with contextual features adaptively. Experimental results demonstrate that TITFormer achieves state-of-the-art performance on two publicly available benchmark datasets.

High affinity is crucial for the efficacy and specificity of antibody. Due to involving high-throughput screens, biological experiments for antibody affinity maturation are time-consuming and have a low success rate. Precise computational-assisted antibody design promises to accelerate this process, but there is still a lack of effective computational methods capable of pinpointing beneficial mutations within the complementarity-determining region (CDR) of antibodies. Moreover, random mutations often lead to challenges in antibody expression and immunogenicity. In this study, to enhance the affinity of a human antibody against avian influenza virus, a CDR library was constructed and evolutionary information was acquired through sequence alignment to restrict the mutation positions and types. Concurrently, a statistical potential methodology was developed based on amino acid interactions between antibodies and antigens to calculate potential affinity-enhanced antibodies, which were further subjected to molecular dynamics simulations. Subsequently, experimental validation confirmed that a point mutation enhancing 2.5-fold affinity was obtained from 10 designs, resulting in the antibody affinity of 2 nM. A predictive model for antibody-antigen interactions based on the binding interface was also developed, achieving an Area Under the Curve (AUC) of 0.83 and a precision of 0.89 on the test set. Lastly, a novel approach involving combinations of affinity-enhancing mutations and an iterative mutation optimization scheme similar to the Monte Carlo method were proposed. This study presents computational methods that rapidly and accurately enhance antibody affinity, addressing issues related to antibody expression and immunogenicity.

G-protein coupled receptors (GPCRs), crucial in various diseases, are targeted of over 40% of approved drugs. However, the reliable acquisition of experimental GPCRs structures is hindered by their lipid-embedded conformations. Traditional protein-ligand interaction models falter in GPCR-drug interactions, caused by limited and low-quality structures. Generalized models, trained on soluble protein-ligand pairs, are also inadequate. To address these issues, we developed two models, DeepGPCR_BC for binary classification and DeepGPCR_RG for affinity prediction. These models use non-structural GPCR-ligand interaction data, leveraging graph convolutional networks and mol2vec techniques to represent binding pockets and ligands as graphs. This approach significantly speeds up predictions while preserving critical physical-chemical and spatial information. In independent tests, DeepGPCR_BC surpassed Autodock Vina and Schrödinger Dock with an area under the curve of 0.72, accuracy of 0.68 and true positive rate of 0.73, whereas DeepGPCR_RG demonstrated a Pearson correlation of 0.39 and root mean squared error of 1.34. We applied these models to screen drug candidates for GPR35 (Q9HC97), yielding promising results with three (F545-1970, K297-0698, S948-0241) out of eight candidates. Furthermore, we also successfully obtained six active inhibitors for GLP-1R. Our GPCR-specific models pave the way for efficient and accurate large-scale virtual screening, potentially revolutionizing drug discovery in the GPCR field.

Generating text from abstract meaning repre-sentation (AMR) is a challenging task. Graph-to-sequence (Graph2Seq-based) methods and pre-trained-based methods are proposed for this task. However, both methods have advantages and disadvantages. Graph2Seq-based methods can make use of the structural information of the graph but not the extra knowledge, while pre-trained-based methods have the advantage of the utilization of extra knowledge but may lose the structural information. In addition, both types of methods often suffer from the under- and over-translation problem. To address these prob-lems, we propose a graph structure reconstruction and coverage enhanced model for this task. The graph structure reconstruction uses two auxiliary objectives, relationship prediction and distance prediction of nodes in AMR graphs to enhance the information of graph structure. In addition, we design a coverage mechanism to solve the problem of information under-translation or over-translation in AMR-to-text generation. Experimental results on three datasets show that our proposed method outperforms the existing methods significantly.

Android, the most popular mobile system, offers a number of user-configurable system settings (e.g., network, location, and permission) for controlling devices and apps. Even popular, well-tested apps may fail to properly adapt their behaviors to diverse setting changes, thus frustrating their users. However, there exists no effort to systematically investigate such defects. To this end, we conduct the first empirical study to understand the characteristics of these setting-related defects (in short as "setting defects"), which reside in apps and are triggered by system setting changes. We devote substantial manual effort (over three person-months) to analyze 1,074 setting defects from 180 popular apps on GitHub. We investigate their impact, root causes, and consequences. We find that setting defects have a wide, diverse impact on apps' correctness, and the majority of these defects (≈70.7%) cause non-crash (logic) failures, and thus could not be automatically detected by existing app testing techniques due to the lack of strong test oracles. Motivated and guided by our study, we propose setting-wise metamorphic fuzzing, the first automated testing approach to effectively detect setting defects without explicit oracles. Our key insight is that an app's behavior should, in most cases, remain consistent if a given setting is changed and later properly restored, or exhibit expected differences if not restored. We realize our approach in SetDroid, an automated, end-to-end GUI testing tool, for detecting both crash and non-crash setting defects. SetDroid has been evaluated on 26 popular, open-source apps and detected 42 unique, previously unknown setting defects in 24 apps. To date, 33 have been confirmed and 21 fixed. We also apply SetDroid on five highly popular industrial apps, namely WeChat, QQMail, TikTok, CapCut, and AlipayHK, all of which each have billions of monthly active users. SetDroid successfully detects 17 previously unknown setting defects in these apps' latest releases, and all defects have been confirmed and fixed by the app vendors. The majority of SetDroid-detected defects (49 out of 59) cause non-crash failures, which could not be detected by existing testing tools (as our evaluation confirms). These results demonstrate SetDroid's strong effectiveness and practicality.

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus poses serious threats to the global public health and leads to worldwide crisis. No effective drug or vaccine is readily available. The viral RNA-dependent RNA polymerase (RdRp) is a promising therapeutic target. A hybrid drug screening procedure was proposed and applied to identify potential drug candidates targeting RdRp from 1906 approved drugs. Among the four selected market available drug candidates, Pralatrexate and Azithromycin were confirmed to effectively inhibit SARS-CoV-2 replication in vitro with EC50 values of 0.008μM and 9.453 μM, respectively. For the first time, our study discovered that Pralatrexate is able to potently inhibit SARS-CoV-2 replication with a stronger inhibitory activity than Remdesivir within the same experimental conditions. The paper demonstrates the feasibility of fast and accurate anti-viral drug screening for inhibitors of SARS-CoV-2 and provides potential therapeutic agents against COVID-19.