Physiological signals are often corrupted by motion artifacts, baseline drift, and other low-SNR disturbances, posing significant challenges for analysis. Additionally, these signals exhibit strong non-stationarity, with sharp peaks and abrupt changes that evolve continuously, making them difficult to represent using traditional time-domain or filtering methods. To address these issues, a novel wavelet-based approach for physiological signal analysis is presented, aimed at capturing multi-scale time-frequency features across various physiological signals. Leveraging this technique, two large-scale pretrained models specific to EMG and ECG are introduced for the first time, achieving superior performance and setting new baselines in downstream tasks. Additionally, a unified multi-modal framework is constructed by integrating a pretrained EEG model, where each modality is guided through its dedicated branch and fused via learnable weighted fusion. This design effectively addresses challenges such as low signal-to-noise ratio, high inter-subject variability, and device mismatch, outperforming existing methods on multi-modal tasks. The proposed wavelet-based architecture lays a solid foundation for the analysis of diverse physiological signals, while the multi-modal design points to next-generation physiological signal processing with potential impacts on wearable health monitoring, clinical diagnostics, and broader biomedical applications. Code and data are available at: github.com/ForeverBlue816/PhysioWave

The electromyography (EMG) signal is particularly useful in monitoring muscle activity, and it can be acquired noninvasively on the skin surface. Thanks to these key characteristics, EMG-based human–machine interfaces (HMIs) for prosthetic myocontrol, as well as gesture recognition, are becoming widespread. A key challenge in this context is to design embedded systems to process EMG signals and generate motor commands with miniaturized, unobtrusive, and low-power devices, reliably and in real time, at a relatively low cost to provide continuous monitoring without causing stigma or discomfort. This article presents an in-depth review of the current status and future research challenges in systems and circuits for EMG acquisition and processing. We start by illustrating the sensor interfaces and acquisition systems required for signal analysis to provide efficient and effective ways of understanding the signal and its nature. We, then, focus on conventional state-of-the-art (SoA) EMG gesture recognition algorithms as well as novel architectures that tackle EMG processing challenges, i.e., hyperdimensional computing (HDC), blind source separation (BSS), and spiking neural networks (SNNs). Finally, we discuss open challenges, such as EMG variability, natural control, and efficient computation, to bring the myocontrol completely out of the laboratory, filling the gap between research prototypes and real-world applications.

Most Wearable Ultrasound (WUS) devices lack the computational power to process signals at the edge, instead relying on remote offload, which introduces latency, high power consumption, and privacy concerns. We present Maestro, a RISC-V SoC with unified Vector-Tensor Unit (VTU) and memory-coupled Fast Fourier Transform (FFT) accelerators targeting edge processing for wearable ultrasound devices, fabricated using low-cost TSMC 65nm CMOS technology. The VTU achieves peak 302GFLOPS/W and 19.8GFLOPS at FP16, while the multi-precision 16/32-bit floating-point FFT accelerator delivers peak 60.6GFLOPS/W and 3.6GFLOPS at FP16. We evaluate Maestro on a US-based gesture recognition task, achieving 1.62GFLOPS in signal processing at 26.68GFLOPS/W, and 19.52GFLOPS in Convolutional Neural Network (CNN) workloads at 298.03GFLOPS/W. Compared to a state-of-the-art SoC with a similar mission profile, Maestro achieves a$5\times $speedup while consuming only 12mW, with an energy consumption of 2.5mJ in a wearable US channel preprocessing and ML-based postprocessing pipeline.