SUMMARY: Many applications of chemical screening are performed in concentration or dose-response mode, and it is necessary to extract appropriate parameters, including whether the chemical/assay pair is active and if so, what are concentrations where activity is seen. Typically, multiple mathematical models or curve shapes are tested against the data to assess the best fit. There are several commercial programs used for this purpose as well as open-source libraries. A widely used system for managing high-throughput screening (HTS) concentration-response data is tcpl (ToxCast Pipeline). The current implementation of tcpl has the concentration-response modeling code tightly integrated with the data management and databasing aspects of HTS data processing. Tcplfit2 is a stand-alone version of the curve-fitting and hitcalling core of tcpl that has been extended to include a large number of standard curve classes and to use benchmark dose modeling. This package will be useful for HTS concentration-response data such as high-throughput whole genome transcriptomics. AVAILABILITY AND IMPLEMENTATION: tcplfit2 is written in R and is available from CRAN.

The analysis of trajectories has become an important field in geographic visualization, as cheap GPS sensors have become commonplace and, in many cases, valuable information can be derived either from the data themselves or their metadata if processed and visualized in the right way. However, showing the "right" information to highlight dependencies or correlations between different measurements remains a challenge, because the technical intricacies of applying a combination of automatic and visual analysis methods prevents the majority of domain experts from analyzing and exploring the full wealth of their movement data. This paper presents an exploration through enrichment approach, which enables iterative generation of metadata based on exploratory findings and is aimed at enabling domain experts to explore their data beyond traditional means.